期刊名：Biologics

期刊主页：https://www.mdpi.com/journal/biologics

我们诚挚邀请您一同探索 Biologics 期刊精选的 2025–2026 年 10 篇高质量文章。本合集聚焦生物制剂与再生医学前沿，涵盖功能水凝胶与骨组织工程、胎儿治疗与新兴生物制剂、补体抑制剂相关感染风险、重度哮喘生物制剂临床缓解、全新蛋白质设计靶向致癌蛋白互作、斑秃细胞因子靶向治疗、紫苏叶提取物抗氧化与细胞应激、制药冻干与 QbD/AI 融合、细胞外基质生物支架免疫应答，以及间充质干细胞及衍生物在神经疾病再生医学中的应用。我们相信，这一合集将成为该领域研究者的重要资源。期刊所有文章均为开放获取，您可以免费且无限制地阅读全部出版内容。

1. Functional Hydrogels in Bone Tissue Engineering: From Material Design to Translational Applications

功能水凝胶在骨组织工程中的应用：从材料设计到转化应用

https://www.mdpi.com/2673-8449/6/1/2

Petraglia, F.M.; Giordano, S.; Santoro, A. Functional Hydrogels in Bone Tissue Engineering: From Material Design to Translational Applications. Biologics 2026, 6, 2.

2. The Evolving Landscape of Fetal Therapy: Surgical Interventions and Emerging Biologics

胎儿治疗领域的发展新态势：手术干预与新兴生物制剂

https://www.mdpi.com/2673-8449/6/2/11

Seker-Yilmaz, B.; Hill, M.; Baranello, G.; Loukogeorgakis, S.; Coppi, P.D.; Gissen, P.; Chitty, L.S. The Evolving Landscape of Fetal Therapy: Surgical Interventions and Emerging Biologics. Biologics 2026, 6, 11.

3 Complement Inhibitors and the Risk of (Breakthrough) Infections—Critical Analysis and Preventive Strategies

补体抑制剂与（突破性）感染风险——批判性分析与预防策略

https://www.mdpi.com/2673-8449/6/1/3

Halacova, N.; Brndiarova, M.; Slenker, B.; Ruzinak Bobcakova, A.; Schniederova, M.; Markocsy, A.; Urbancikova, I.; Jesenak, M. Complement Inhibitors and the Risk of (Breakthrough) Infections—Critical Analysis and Preventive Strategies. Biologics 2026, 6, 3.

4. Clinical Remission and Its Predictors After 12 Months of Biologic Therapy in Severe Asthma

重度哮喘患者接受生物制剂治疗12个月后的临床缓解及其预测因素

https://www.mdpi.com/2673-8449/6/1/4

Suzuki, T.; Tajiri, T.; Ozawa, Y.; Amakusa, Y.; Ito, K.; Mori, Y.; Fukumitsu, K.; Fukuda, S.; Kanemitsu, Y.; Uemura, T.; et al. Clinical Remission and Its Predictors After 12 Months of Biologic Therapy in Severe Asthma. Biologics 2026, 6, 4.

5. De Novo Protein Design Enables Targeting of Intractable Oncogenic Protein–Protein Interfaces

全新蛋白质设计使得能够靶向难治性致癌蛋白-蛋白相互作用界面

https://www.mdpi.com/2673-8449/6/1/9

Ram Prakash, V.; Najy, Y.; Garrett, K.; Edwards, B.F.P.; Kidder, B.L. De Novo Protein Design Enables Targeting of Intractable Oncogenic Protein–Protein Interfaces. Biologics 2026, 6, 9.

6. Cytokine-Targeting Biologic Therapies for Alopecia Areata: A Comprehensive Review of Mechanism of Action, Clinical Efficacy, and Adverse Events

针对斑秃的细胞因子靶向生物制剂疗法：作用机制、临床疗效及不良反应的全面综述

https://www.mdpi.com/2673-8449/5/2/11

Gaumond, S.I.; Kamholtz, I.; Jimenez, J.J. Cytokine-Targeting Biologic Therapies for Alopecia Areata: A Comprehensive Review of Mechanism of Action, Clinical Efficacy, and Adverse Events. Biologics 2025, 5, 11.

7. Analysis of Polyphenolic Composition, Antioxidant Power and Stress-Response Effects of Fractionated Perilla Leaf Extract on Cells In Vitro

紫苏叶分级提取物的多酚成分分析、抗氧化能力及体外细胞应激反应效应研究

https://www.mdpi.com/2673-8449/5/1/2

Lia, F.; Baron, B. Analysis of Polyphenolic Composition, Antioxidant Power and Stress-Response Effects of Fractionated Perilla Leaf Extract on Cells In Vitro. Biologics 2025, 5, 2.

8. Advancements in Pharmaceutical Lyophilization: Integrating QbD, AI, and Novel Formulation Strategies for Next-Generation Biopharmaceuticals

制药冻干技术的进步：融合质量源于设计（QbD）、人工智能（AI）与新型制剂策略，推动下一代生物制药的发展

https://www.mdpi.com/2673-8449/5/4/35

Atre, P.; Rizvi, S.A.A. Advancements in Pharmaceutical Lyophilization: Integrating QbD, AI, and Novel Formulation Strategies for Next-Generation Biopharmaceuticals. Biologics 2025, 5, 35.

9. Immune Response to Extracellular Matrix Bioscaffolds: A Comprehensive Review

细胞外基质生物支架免疫应答机制的全面综述

https://www.mdpi.com/2673-8449/5/3/28

Romero, D.J.; Hussey, G.; Capella-Monsonís, H. Immune Response to Extracellular Matrix Bioscaffolds: A Comprehensive Review. Biologics 2025, 5, 28.

10. Mesenchymal Stem Cells and Their Derivatives: Old Problems and New Possibilities in Regenerative Medicine for Neurological Diseases

间充质干细胞及其衍生物：神经系统疾病再生医学中的既有难题与新机遇https://www.mdpi.com/2673-8449/5/4/37

Akhmetzyanova, E.; Shulman, I.; Fakhrutdinova, T.; Rizvanov, A.; Mukhamedshina, Y. Mesenchymal Stem Cells and Their Derivatives: Old Problems and New Possibilities in Regenerative Medicine for Neurological Diseases. Biologics 2025, 5, 37.

期刊介绍

主编：Prof. Dr. Gary McLean

Biologics (ISSN 2673-8449) 是一个国际型开放获取英文学术期刊，旨在发表新兴和成熟生物制剂领域的研究成果, 为相关领域的学者提供一个学术交流的平台。目前期刊开设疫苗、诊断相关生物制剂、血液制品、单克隆抗体、细胞因子及相关介质、激素、蛋白质疗法、天然产物8个栏目。期刊目前已被Scopus, EBSCO, DOAJ等多个数据库收录.

2025 CiteScore：3.7

Time to First Decision：32.7 Days

Acceptance to Publication：4.7 Days