期刊名：Pathophysiology

期刊主页：https://www.mdpi.com/journal/pathophysiology

• 本期导读

本期高引文章荐读涵盖了代谢、免疫与炎症交叉领域的7篇前沿综述与研究，为相关疾病的机制探索与临床干预提供了新视角。在代谢性疾病方面，揭示了线粒体功能障碍在糖尿病发病中的核心作用，并报道了肝脏雌激素受体α过表达通过改善肝细胞线粒体功能来减轻胰岛素抵抗与脂肪肝的保护效应。在自身免疫领域，相关综述分别解析了系统性红斑狼疮中天然与适应性免疫的失调网络，以及自身免疫性甲状腺疾病中微量元素与心血管健康的复杂关联。此外，肾脏生理学系统梳理为临床尿液综合评估提供了实用框架；生活方式干预在癌症防治中的循证证据得到全面总结；RAGE-Diaph1信号通路在神经退行性疾病中的病理机制则为其治疗提供了新视角，体现了从基础研究到临床转化的多元探索。

精选文章

1. Mitochondrial Dysfunction in Diabetes: Shedding Light on a Widespread Oversight

糖尿病中的线粒体功能障碍：揭示一个被广泛忽视的问题

http://www.mdpi.com/1873-149X/32/1/9

Iheagwam, F.N.; Joseph, A.J.; Adedoyin, E.D.; Iheagwam, O.T.; Ejoh, S.A. Mitochondrial Dysfunction in Diabetes: Shedding Light on a Widespread Oversight. Pathophysiology 2025, 32, 9.

2. Hepatic Estrogen Receptor Alpha Overexpression Protects Against Hepatic Insulin Resistance and MASLD

肝脏雌激素受体α过表达对肝脏胰岛素抵抗及代谢功能障碍相关脂肪性肝病（MASLD）的保护作用

http://www.mdpi.com/1873-149X/32/1/1

Alves, E.S.; Santos, J.D.M.; Cruz, A.G.; Camargo, F.N.; Talarico, C.H.Z.; Santos, A.R.M.; Silva, C.A.A.; Morgan, H.J.N.; Matos, S.L.; Araujo, L.C.C.; et al. Hepatic Estrogen Receptor Alpha Overexpression Protects Against Hepatic Insulin Resistance and MASLD. Pathophysiology 2025, 32, 1.

3. Understanding Renal Tubular Function: Key Mechanisms, Clinical Relevance, and Comprehensive Urine Assessment

理解肾小管功能：关键机制、临床相关性与综合尿液评估

http://www.mdpi.com/1873-149X/32/3/33

Alamilla-Sanchez, M.; Alcalá Salgado, M.A.; Ulloa Galván, V.M.; Yanez Salguero, V.; Yamá Estrella, M.B.; Morales López, E.F.; Ramos García, N.A.; Carbajal Zárate, M.O.; Salazar Hurtado, J.D.; Delgado Pineda, D.A.; et al. Understanding Renal Tubular Function: Key Mechanisms, Clinical Relevance, and Comprehensive Urine Assessment. Pathophysiology 2025, 32, 33.

4. Immunopathogenesis of Systemic Lupus Erythematosus: Interplay of Innate and Adaptive Immunity, Microbiome Dysbiosis, and Emerging Therapeutic Targets

系统性红斑狼疮的免疫发病机制：先天性与适应性免疫的相互作用、微生物群失调及新兴治疗靶点

http://www.mdpi.com/1873-149X/32/4/61

Ahmed, A.; Li, S.; Yu, J.J.; Shao, W.-H. Immunopathogenesis of Systemic Lupus Erythematosus: Interplay of Innate and Adaptive Immunity, Microbiome Dysbiosis, and Emerging Therapeutic Targets. Pathophysiology 2025, 32, 61.

5. Nutrition and Micronutrient Interactions in Autoimmune Thyroid Disorders: Implications for Cardiovascular Health

自身免疫性甲状腺疾病中的营养与微量元素交互作用：对心血管健康的影响

http://www.mdpi.com/1873-149X/32/3/37

Mazur, M.; Szymańska, M.; Malik, A.; Szlasa, W.; Popiolek-Kalisz, J. Nutrition and Micronutrient Interactions in Autoimmune Thyroid Disorders: Implications for Cardiovascular Health. Pathophysiology 2025, 32, 37.

6. Lifestyle-Based Approaches to Cancer Prevention and Treatment: Diet, Physical Activity, and Integrative Strategies

基于生活方式的癌症预防与治疗策略：饮食、体力活动与综合策略

http://www.mdpi.com/1873-149X/32/4/70

Greco, G.; Petrelli, A.; Fischetti, F.; Cataldi, S. Lifestyle-Based Approaches to Cancer Prevention and Treatment: Diet, Physical Activity, and Integrative Strategies. Pathophysiology 2025, 32, 70.

7. Current Evidence on the Involvement of RAGE–Diaph1 Signaling in the Pathology and Treatment of Neurodegenerative Diseases—An Overview

RAGE–Diaph1信号通路参与神经退行性疾病病理与治疗的现有证据——概述

http://www.mdpi.com/1873-149X/32/3/43

Juranek, J.K.; Kordas, B.; Podlasz, P.; Bossowska, A.; Banach, M. Current Evidence on the Involvement of RAGE–Diaph1 Signaling in the Pathology and Treatment of Neurodegenerative Diseases—An Overview. Pathophysiology 2025, 32, 43.

期刊介绍

主编：Jonathan Steven Alexander, LSU Health Shreveport, USA

期刊旨在发表与病理过程的病因、发展和消除相关的研究。现已被ESCI (Web of Science)、Scopus、PMC、PubMed等多个数据库收录。

2025 Impact Factor： 3.5

2025 CiteScore： 5.1

Time to First Decision： 27.7 Days

Acceptance to Publication：2.9 Days