论文标题：Heterogeneity of the tumor immune microenvironment and clinical interventions

期刊： Frontiers of Medicine

作者：Zheng Jin, Qin Zhou, Jia-Nan Cheng, Qingzhu Jia, Bo Zhu

发表时间：15 Aug 2023

DOI： 10.1007/s11684-023-1015-9

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导 读

陆军军医大学朱波团队在Frontiers of Medicine发表综述论文《肿瘤免疫微环境的异质性及临床干预措施》（Heterogeneity of the tumor immune microenvironment and clinical interventions）。本文系统综述了肿瘤免疫微环境的异质性形成机制，介绍了单细胞转录组测序等前沿技术，总结了基于调控肿瘤细胞基因等机制的临床干预策略，为克服异质性、优化肿瘤治疗提供了依据和方向。

The tumor immune microenvironment (TIME) is broadly composed of various immune cells, and its heterogeneity is characterized by both immune cells and stromal cells. During the course of tumor formation and progression and anti-tumor treatment, the composition of the TIME becomes heterogeneous. Such immunological heterogeneity is not only present between populations but also exists on temporal and spatial scales. Owing to the existence of TIME, clinical outcomes can differ when a similar treatment strategy is provided to patients. Therefore, a comprehensive assessment of TIME heterogeneity is essential for developing precise and effective therapies. Facilitated by advanced technologies, it is possible to understand the complexity and diversity of the TIME and its influence on therapy responses. In this review, we discuss the potential reasons for TIME heterogeneity and the current approaches used to explore it. We also summarize clinical intervention strategies based on associated mechanisms or targets to control immunological heterogeneity.

肿瘤免疫微环境（TIME）由多种免疫细胞构成，其异质性特征表现为免疫细胞和间质细胞两方面的特征。在肿瘤形成、进展及抗肿瘤治疗过程中，TIME的组成呈现动态异质性。这种免疫异质性不仅存在于不同患者群体间，也在时间与空间维度上存在差异。由于TIME的存在，当为患者提供相似的治疗策略时，临床结局可能存在差异。因此，全面评估TIME异质性对于制定精准有效的治疗方案至关重要。借助前沿技术，研究人员得以了解TIME的复杂性和多样性及其对治疗应答的影响。本综述探讨了TIME异质性的潜在成因及当前用于解析该异质性的研究方法，并基于相关机制或靶点总结了临床干预策略，以期实现对免疫异质性的调控。

期刊介绍

Frontiers of Medicine专注于发表临床医学和基础医学领域的最新研究成果，旨在通过全球医疗专业人员之间的交流促进健康和医疗保健的发展。该刊采用严格的同行评审和编辑流程，确保发表的文章的科学准确性、新颖性和重要性。

原文信息

标题

Heterogeneity of the tumor immune microenvironment and clinical interventions

作者

Zheng Jin^1,2,3,4, Qin Zhou^1,2,5, Jia-Nan Cheng^1,2, Qingzhu Jia^1,2, Bo Zhu^1,2

机构

1. Department of Oncology, Xinqiao Hospital, Army Medical University, Chongqing 400037, China

2. Key Laboratory of Tumor Immunotherapy, Chongqing 400037, China

3. Research Institute, GloriousMed Clinical Laboratory (Shanghai) Co. Ltd., Shanghai 201318, China

4. Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, China

5. School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China

通讯作者

Jia-Nan Cheng, Qingzhu Jia, Bo Zhu

引用这篇文章

Zheng Jin, Qin Zhou, Jia-Nan Cheng, Qingzhu Jia, Bo Zhu. Heterogeneity of the tumor immune microenvironment and clinical interventions. Front. Med., 2023, 17(4): 617–648 https://doi.org/10.1007/s11684-023-1015-9

https://journal.hep.com.cn/fmd/EN/10.1007/s11684-023-1015-9

https://link.springer.com/article/10.1007/s11684-023-1015-9

感谢作者对Frontiers of Medicine的信任和支持。

《前沿》系列英文学术期刊

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