期刊名： Organoids

期刊主页：https://www.mdpi.com/journal/organoids

类器官是一种由干细胞衍生的三维多细胞组织构建物，能够模拟相应器官的结构和功能。作为一种新兴的体外模型，类器官技术在过去几十年中迅速发展，逐渐成为生物医学研究的重要工具。本专题汇集了发表于 Organoids 期刊的系列前沿研究，系统呈现了类器官技术在多种组织器官中的构建策略与多元应用，涵盖三维培养体系、药物筛选、疾病模型构建及精准医疗等重要方向。诚邀广大相关领域研究者深入阅读本专题文章。本刊所有文章均以开放获取形式出版，可供读者免费、无限制地访问全文。

1. Precision Medicine for Gastric Cancer: Current State of Organoid Drug Testing

胃癌精准医疗：类器官药物检测现状

https://www.mdpi.com/2674-1172/3/4/16

Silva, T.N.; Wright, J.A.; Worthley, D.L.; Woods, S.L. Precision Medicine for Gastric Cancer: Current State of Organoid Drug Testing. Organoids 2024, 3, 266–280. https://doi.org/10.3390/organoids3040016

2. Establishment and Validation of Patient-Derived Non-Small Cell Lung Cancer Organoids as In Vitro Lung Cancer Models

患者来源非小细胞肺癌类器官的构建与验证：体外肺癌研究模型

https://www.mdpi.com/2674–1172/3/4/17

Werner, R.S.; Jang, J.-H.; Rechsteiner, M.; Kirschner, M.B.; Opitz, I. Establishment and Validation of Patient-Derived Non-Small Cell Lung Cancer Organoids as In Vitro Lung Cancer Models. Organoids 2024, 3, 281–294. https://doi.org/10.3390/organoids3040017

3. Precision Medicine for Peritoneal Carcinomatosis—Current Advances in Organoid Drug Testing and Clinical Applicability

腹膜癌病的精准医疗——类器官药物检测与临床应用的最新进展

https://www.mdpi.com/2674-1172/4/1/2

Kaur, H.; Wright, J.A.; Worthley, D.L.; Murphy, E.; Woods, S.L. Precision Medicine for Peritoneal Carcinomatosis—Current Advances in Organoid Drug Testing and Clinical Applicability. Organoids 2025, 4, 2. https://doi.org/10.3390/organoids4010002

4. Visualization of Vascular Perfusion of Human Pancreatic Cancer Tissue in the CAM Model and Its Impact on Future Personalized Drug Testing

CAM模型中人类胰腺癌组织血管灌注的可视化及其对未来个性化药物测试的启示

https://www.mdpi.com/2674-1172/3/1/1

Ettner-Sitter, A.; Montagner, A.; Kuenzel, J.; Brackmann, K.; Schäfer, M.; Schober, R.; Weber, F.; Aung, T.; Hackl, C.; Haerteis, S. Visualization of Vascular Perfusion of Human Pancreatic Cancer Tissue in the CAM Model and Its Impact on Future Personalized Drug Testing. Organoids 2024, 3, 1–17. https://doi.org/10.3390/organoids3010001

5. Human Nasal Epithelium Organoids for Assessing Neutralizing Antibodies to a Protective SARS-CoV-2 Virus-like Particle Vaccine

人鼻上皮类器官评估保护性SARS-CoV-2病毒样颗粒疫苗的中和抗体

https://www.mdpi.com/2674-1172/3/1/2

Carrera Montoya, J.; Collett, S.; Fernandez Ruiz, D.; Earnest, L.; Edeling, M.A.; Yap, A.H.Y.; Wong, C.Y.; Cooney, J.P.; Davidson, K.C.; Roberts, J.; et al. Human Nasal Epithelium Organoids for Assessing Neutralizing Antibodies to a Protective SARS-CoV-2 Virus-like Particle Vaccine. Organoids 2024, 3, 18–31. https://doi.org/10.3390/organoids3010002

6. Combining Proteomics and Organoid Research to Unravel the Multifunctional Complexity of Kidney Physiology Enhances the Need for Controlled Organoid Maturation

蛋白质组学与类器官研究的结合以揭示肾脏生理的多功能复杂性：推进类器官可控成熟体系的构建需求

https://www.mdpi.com/2674-1172/4/4/28

Groeneveld, K.; Mrowka, R. Combining Proteomics and Organoid Research to Unravel the Multifunctional Complexity of Kidney Physiology Enhances the Need for Controlled Organoid Maturation. Organoids 2025, 4, 28. https://doi.org/10.3390/organoids4040028

7. Assessing the Utility of Organoid Intelligence: Scientific and Ethical Perspectives

类器官智能的实用性评估：科学及伦理考量

https://www.mdpi.com/2674-1172/4/2/9

Nestor, M.W.; Wilson, R.L. Assessing the Utility of Organoid Intelligence: Scientific and Ethical Perspectives. Organoids 2025, 4, 9. https://doi.org/10.3390/organoids4020009

8. Recent Advances and Future Perspectives in Vascular Organoids and Vessel-on-Chip

血管类器官与血管芯片的研究进展与未来展望

https://www.mdpi.com/2674-1172/3/3/14

Cheruku, G.R.; Wilson, C.V.; Raviendran, S.; Xiao, Q. Recent Advances and Future Perspectives in Vascular Organoids and Vessel-on-Chip. Organoids 2024, 3, 203–246. https://doi.org/10.3390/organoids3030014

9. Improved Differentiation of Human Retinal Organoids Producing Mature Photoreceptors with Budding Calyceal Process-like Structure and Usher Protein Expression

优化人视网膜类器官分化：生成带有萼突样萌芽结构、表达 Usher 蛋白的成熟感光细胞

https://www.mdpi.com/2674-1172/4/4/27

Matsushita, T.; Matsuyama, T.; Kawasaki, T.; Uchiumi, F. Improved Differentiation of Human Retinal Organoids Producing Mature Photoreceptors with Budding Calyceal Process-like Structure and Usher Protein Expression. Organoids 2025, 4, 27. https://doi.org/10.3390/organoids4040027

10. Trophoblast Organoids: Capturing the Complexity of Early Placental Development In Vitro

滋养层类器官：体外再现早期胎盘发育的复杂性

https://www.mdpi.com/2674-1172/3/3/12

Wessel, B.M.; Castro, J.N.; Roberts, V.H.J. Trophoblast Organoids: Capturing the Complexity of Early Placental Development In Vitro. Organoids 2024, 3, 174-193. https://doi.org/10.3390/organoids3030012

11. Generation of Trophoblast Organoids from Chorionic Villus Sampling

基于绒毛穿刺样本构建滋养层类器官

https://www.mdpi.com/2674-1172/3/1/5

van Rijn, B.; Van Opstal, D.; van Koetsveld, N.; Knapen, M.; Gribnau, J.; Schäffers, O. Generation of Trophoblast Organoids from Chorionic Villus Sampling. Organoids 2024, 3, 54–66. https://doi.org/10.3390/organoids3010005

12. Organoid Models of Lymphoid Tissues

淋巴组织类器官模型

https://www.mdpi.com/2674-1172/4/2/7

Bogoslowski, A.; Ren, J.; Quintard, C.; Penninger, J.M. Organoid Models of Lymphoid Tissues. Organoids 2025, 4, 7. https://doi.org/10.3390/organoids4020007

13. Breaking and Remaking: Using Organoids to Model Gastric Tissue Damage and Repair

破坏与重建：使用类器官构建胃组织损伤与修复模型

https://www.mdpi.com/2674-1172/4/3/20

Liddelow, N.; Tan, J.Y.; Flanagan, D.J. Breaking and Remaking: Using Organoids to Model Gastric Tissue Damage and Repair. Organoids 2025, 4, 20. https://doi.org/10.3390/organoids4030020

14. Three-Dimensional Culture Systems in Neuroblastoma Research

神经母细胞瘤研究中的三维培养体系

https://www.mdpi.com/2674-1172/4/2/10

Jung, P.; Wolpaw, A.J. Three-Dimensional Culture Systems in Neuroblastoma Research. Organoids 2025, 4, 10. https://doi.org/10.3390/organoids4020010

15. Development and Optimization of a Lactate Dehydrogenase Assay Adapted to 3D Cell Cultures

3D细胞培养中乳酸脱氢酶检测方法的建立与优化

https://www.mdpi.com/2674-1172/3/2/8

Castiglione, H.; Madrange, L.; Lemonnier, T.; Deslys, J.-P.; Yates, F.; Vigneron, P.-A. Development and Optimization of a Lactate Dehydrogenase Assay Adapted to 3D Cell Cultures. Organoids 2024, 3, 113–125. https://doi.org/10.3390/organoids3020008

期刊介绍

主编：Prof. Dr. Süleyman Ergün

Organoids（ISSN 2674-1172）是一个国际性、经过严格同行评审的开放获取学术期刊，致力于发表类器官领域的高质量研究，为全球科学家搭建分享与交流的权威平台。期刊聚焦类器官发育各方面的前沿研究，涵盖干细胞与祖细胞分化技术，以及在组织工程、生物打印、类器官模型构建及生物医学应用中的技术进展。期刊已被ESCI (Web of Science)、Scopus、EBSCO、DOAJ等数据库收录。

2025 Impact Factor：2.8

2024 CiteScore：4.3

Time to First Decision：26.3 Days

Acceptance to Publication：5.6 Days