期刊名：Antioxidants

期刊主页：https://www.mdpi.com/journal/antioxidants

肝脏疾病是全球范围内发病率和死亡率居高不下的重大公共卫生问题，脂肪肝、病毒性肝炎、肝纤维化及肝癌等疾病进展隐匿，早期常伴随明显的代谢紊乱、氧化应激损伤及免疫微环境失衡，最终导致肝细胞损伤、炎症级联反应及肝功能进行性衰退。近年来，针对肝脏疾病关键病理环节的干预策略研究持续升温。本期文献清单精选多篇前沿论著，涵盖代谢相关脂肪性肝病、急性与慢性肝损伤、肝纤维化等多种肝病类型，围绕铁代谢紊乱、线粒体功能异常、内质网应激、肠道菌群失衡、缺氧应激等核心病理机制展开深度探究，阐释铁死亡、氧化应激、炎症凋亡等关键生物学过程调控肝病进展的分子通路，同时挖掘各类天然活性物质与微生态干预手段的肝保护效应及作用机制，系统呈现了肝病发生发展中的核心机制、关键调控通路与潜在药物干预靶点，旨在为揭示肝脏疾病的发病本质、推动临床转化研究及开发新型治疗手段提供有力的学术支撑与参考视角。

1. Iron, Oxidative Stress, and Metabolic Dysfunction—Associated Steatotic Liver Disease

铁、氧化应激与代谢功能障碍相关脂肪性肝病

https://www.mdpi.com/2076-3921/13/2/208

Gensluckner, S.; Wernly, B.; Datz, C.; Aigner, E. Iron, Oxidative Stress, and Metabolic Dysfunction—Associated Steatotic Liver Disease. Antioxidants 2024, 13, 208.

2. Hepatoprotective Effects of Flavonoids against Benzo[a]Pyrene-Induced Oxidative Liver Damage along Its Metabolic Pathways

黄酮类化合物对苯并[a]芘在其代谢途径中诱导的氧化性肝损伤的保肝作用

https://www.mdpi.com/2076-3921/13/2/180

Kim, M.; Jee, S.-C.; Sung, J.-S. Hepatoprotective Effects of Flavonoids against Benzo[a]Pyrene-Induced Oxidative Liver Damage along Its Metabolic Pathways. Antioxidants 2024, 13, 180.

3. Gut Microbiota and Metabolic Dysfunction-Associated Steatotic Liver Disease

肠道菌群与代谢功能障碍相关脂肪性肝病

https://www.mdpi.com/2076-3921/13/11/1386

Scarpellini, E.; Scarcella, M.; Tack, J.F.; Scarlata, G.G.M.; Zanetti, M.; Abenavoli, L. Gut Microbiota and Metabolic Dysfunction-Associated Steatotic Liver Disease. Antioxidants 2024, 13, 1386.

4. The PERK-eIF2α-ATF4 Axis Is Involved in Mediating ER-Stress-Induced Ferroptosis via DDIT4-mTORC1 Inhibition and Acetaminophen-Induced Hepatotoxicity

PERK-eIF2α-ATF4轴经由DDIT4-mTORC1通路抑制参与介导内质网应激诱发的铁死亡及对乙酰氨基酚肝损伤

https://www.mdpi.com/2076-3921/14/3/307#

Nghiem, T.-H.T.; Nguyen, K.A.; Kusuma, F.; Park, S.; Park, J.; Joe, Y.; Han, J.; Chung, H.T. The PERK-eIF2α-ATF4 Axis Is Involved in Mediating ER-Stress-Induced Ferroptosis via DDIT4-mTORC1 Inhibition and Acetaminophen-Induced Hepatotoxicity. Antioxidants 2025, 14, 307.

5. Coffee Compounds Protection Against Lipotoxicity Is Associated with Lipid Droplet Formation and Antioxidant Response in Primary Rat Hepatocytes

咖啡化合物对脂毒性的保护作用与大鼠原代肝细胞内脂滴形成及抗氧化应答相关

https://www.mdpi.com/2076-3921/14/2/175

Arroyave-Ospina, J.C.; Martínez, M.; Buist-Homan, M.; Palasantzas, V.; Arrese, M.; Moshage, H. Coffee Compounds Protection Against Lipotoxicity Is Associated with Lipid Droplet Formation and Antioxidant Response in Primary Rat Hepatocytes. Antioxidants 2025, 14, 175.

6. Long-Term Consumption of Hydrogen-Rich Water Mitigates Oxidative Stress, Hepatic Inflammation, and Apoptosis in Rats with LPS-Induced Chronic Liver Injury

长期饮用富氢水可减轻LPS诱导的慢性肝损伤大鼠的氧化应激、肝脏炎症及细胞凋亡

https://www.mdpi.com/2076-3921/15/2/260

Zhang, L.; Wang, H.; Mai, Y.; He, Q.; Liu, T.; Zhang, N.; Zhang, J. Long-Term Consumption of Hydrogen-Rich Water Mitigates Oxidative Stress, Hepatic Inflammation, and Apoptosis in Rats with LPS-Induced Chronic Liver Injury. Antioxidants 2026, 15, 260.

7. Effects of Melatonin and Akkermansia muciniphila on the Gut-Liver Axis in a MASLD-Associated Liver Fibrosis Model: An Integrative Multi-Omic Approach

褪黑素与嗜黏蛋白阿克曼菌对MASLD相关肝纤维化模型中肠-肝轴的影响：一项整合多组学研究

https://www.mdpi.com/2076-3921/15/3/306

González-Robles, A.; San Miguel, B.; Román-Sagüillo, S.; Juárez-Fernández, M.; Mauriz, J.L.; Martínez-Flórez, S.; Nistal, E.; García-Mediavilla, M.V.; Sánchez-Campos, S. Effects of Melatonin and Akkermansia muciniphila on the Gut-Liver Axis in a MASLD-Associated Liver Fibrosis Model: An Integrative Multi-Omic Approach. Antioxidants 2026, 15, 306.

期刊介绍

主编：Prof. Dr. Alessandra Napolitano, University of Naples “Federico II”,Italy;

副主编：刘健康教授，西安交通大学/康复大学，中国

Antioxidants (ISSN 2076-3921) 是一个国际型开放获取英文学术期刊，期刊为抗氧化剂科学和技术的相关研究提供了一个发表平台，重点关注活性物种、生物相关过程、天然产物和食品中活性物质的抗氧化性能、作用机制、应用和用途的新见解和想法。期刊在 Web of Science Journal Citation Reports 数据库的 Medicinal Chemistry、Food Science & Technology 和 Biochemistry & Molecular Biology 三个分区中皆为 1 区。期刊5年 IF 为8.5。

2025 Impact Factor：8.2

2025 CiteScore：14.7

Time to First Decision：18.7 Days

Acceptance to Publication：2.9 Days