期刊名：Toxics

期刊主页：https://www.mdpi.com/journal/toxics

6-PPD醌（6PPD-Quinone，简称6PPD-Q）是一种由轮胎防老剂6-PPD在环境中与臭氧反应生成的具有高毒性的衍生物。它广泛存在于城市道路径流中，对生物和生态安全构成潜在威胁。本期文献清单为您汇总Toxics期刊“6-PPD醌”方向的文章，助您快速掌握前沿进展，拓展科研思路。

1. Not Just a Fish Killer: Multi-Organ Toxicity and Mechanisms of 6PPD-Quinone

不仅仅是鱼类杀手：6PPD-醌的多脏器毒性及其机制

https://www.mdpi.com/2305-6304/14/4/288

Dong, P.; Liu, M.; Wang, H.; Chen, J.; Xu, X.; Su, H.; Qin, M.; Luo, J. Not Just a Fish Killer: Multi-Organ Toxicity and Mechanisms of 6PPD-Quinone. Toxics 2026, 14(4), 288. https://doi.org/10.3390/toxics14040288.

2. 6-PPD Quinone Inhibits Phosphatidic Acid Synthesis Associated with an Increase in Intestinal Barrier Permeability in C. elegans

6-PPD醌抑制与秀丽隐杆线虫肠道屏障通透性增加相关的磷脂酸合成

https://www.mdpi.com/2305-6304/14/3/254

Wu, J.; Bian, Q.; Wang, D. 6-PPD Quinone Inhibits Phosphatidic Acid Synthesis Associated with an Increase in Intestinal Barrier Permeability in C. elegans. Toxics 2026, 14(3), 254. https://doi.org/10.3390/toxics14030254.

3. Solid-Phase Extraction Based on Captiva EMR-Lipid for Determination of 19 Aromatic Amine Antioxidants and Two p-Phenylenediamine Quinones in Human Plasma

基于Captiva EMR-Lipid的固相萃取法，用于人类血浆中19种芳香胺抗氧化剂和两种对苯二胺醌的测定

https://www.mdpi.com/2305-6304/14/3/187

Liang, B.; Deng, Q.; Pan, Z.; Du, B.; Zeng, L. Solid-Phase Extraction Based on Captiva EMR-Lipid for Determination of 19 Aromatic Amine Antioxidants and Two p-Phenylenediamine Quinones in Human Plasma. Toxics 2026, 14(3), 187. https://doi.org/10.3390/toxics14030187.

4. Advances in Analytical Determination Methods and Toxicity and Health Risk Assessment of 6PPD and Its Transformation Products in Food

6PPD及其转化产物在食品中的分析检测方法进展及毒性与健康风险评估

https://www.mdpi.com/2305-6304/13/12/1076

Liu, B.; Liu, Y.; Zhan, Z.; Xie, J.; Ding, G.; Zhao, Z. Advances in Analytical Determination Methods and Toxicity and Health Risk Assessment of 6PPD and Its Transformation Products in Food. Toxics 2025, 13(12), 1076. https://doi.org/10.3390/toxics13121076.

5. Study on Hepatotoxicity of Benzophenone-3 at Environmental Concentration in Postpartum Mice

环境浓度下苯基苯酮-3对产后小鼠肝脏毒性的研究

https://www.mdpi.com/2305-6304/13/12/1014

Zhai, H.-F.; Tian, Y.-N.; Sheng, Y.-X.; Pu, Y.-J.; Gao, Y.-R.; Chen, J.-Y.; Liu, J.-D.; Ma, J.; Xu, H.-M.; Yang, P.-B.; Li, H.-M. Study on Hepatotoxicity of Benzophenone-3 at Environmental Concentration in Postpartum Mice. Toxics 2025, 13(12), 1014. https://doi.org/10.3390/toxics13121014.

6. Environmental Occurrence, Influencing Factors, and Toxic Effects of 6PPD-Q

6PPD醌的环境存在、影响因素及毒性效应

https://www.mdpi.com/2305-6304/13/11/906

Yin, T.; Liang, Y.; Liu, Y.; Liu, J.; Wang, X. Environmental Occurrence, Influencing Factors, and Toxic Effects of 6PPD-Q. Toxics 2025, 13(11), 906. https://doi.org/10.3390/toxics13110906.

7. Exposure to 6-PPD Quinone Disrupts Adsorption and Catabolism of Leucine and Causes Mitochondrial Dysfunction in Caenorhabditis elegans

暴露于6-PPD醌破坏亮氨酸的吸收和代谢，并导致秀丽隐杆线虫线粒体功能障碍

https://www.mdpi.com/2305-6304/13/7/544

Wang, W.; Li, Y.; Wang, D. Exposure to 6-PPD Quinone Disrupts Adsorption and Catabolism of Leucine and Causes Mitochondrial Dysfunction in Caenorhabditis elegans. Toxics 2025, 13(7), 544. https://doi.org/10.3390/toxics13070544.

8. Network Toxicology and Molecular Docking to Elucidate the Mechanisms of Intestinal Toxicity Induced by P-Phenylenediamine Antioxidants and Their Quinone Derivatives

网络毒理学与分子对接技术用于阐明对苯二胺抗氧化剂及其醌类衍生物引起的肠道毒性机制

https://www.mdpi.com/2305-6304/13/6/480

Zou, H.; Tan, Y.; Ren, X.; Li, Z.; Liu, Y. Network Toxicology and Molecular Docking to Elucidate the Mechanisms of Intestinal Toxicity Induced by P-Phenylenediamine Antioxidants and Their Quinone Derivatives. Toxics 2025, 13(6), 480. https://doi.org/10.3390/toxics13060480.

9. Long-Term Exposure to 6-PPD Quinone Inhibits Glutamate Synthesis and Glutamate Receptor Function Associated with Its Toxicity Induction in Caenorhabditis elegans

长期暴露于6-PPD醌抑制谷氨酸合成和谷氨酸受体功能，与其在秀丽隐杆线虫中诱导毒性相关

https://www.mdpi.com/2305-6304/13/6/434

Wang, W.; Li, Y.; Wang, D. Long-Term Exposure to 6-PPD Quinone Inhibits Glutamate Synthesis and Glutamate Receptor Function Associated with Its Toxicity Induction in Caenorhabditis elegans. Toxics 2025, 13(6), 434. https://doi.org/10.3390/toxics13060434.

10. A Review of N-(1,3-Dimethylbutyl)-N′-phenyl-p-Phenylenediamine (6PPD) and Its Derivative 6PPD-Quinone in the Environment

N-(1,3-二甲基丁基)-N′-苯基-对苯二胺（6PPD）及其衍生物6PPD-醌在环境中的综述

https://www.mdpi.com/2305-6304/12/6/394

Li, Y.; Zeng, J.; Liang, Y.; Zhao, Y.; Zhang, S.; Chen, Z.; Zhang, J.; Shen, X.; Wang, J.; Zhang, Y.; Sun, Y. A Review of N-(1,3-Dimethylbutyl)-N′-phenyl-p-Phenylenediamine (6PPD) and Its Derivative 6PPD-Quinone in the Environment. Toxics 2024, 12(6), 394. https://doi.org/10.3390/toxics12060394.

11. Effects of 6PPD-Quinone on Human Liver Cell Lines as Revealed with Cell Viability Assay and Metabolomics Analysis

6PPD-醌对人类肝细胞系的影响：细胞活力测定和代谢组学分析的揭示

https://www.mdpi.com/2305-6304/12/6/389

Qi, Y.; Qiu, A.; Wei, X.; Huang, Y.; Huang, Q.; Huang, W. Effects of 6PPD-Quinone on Human Liver Cell Lines as Revealed with Cell Viability Assay and Metabolomics Analysis. Toxics 2024, 12(6), 389. https://doi.org/10.3390/toxics12060389.

12. Environmental and Human Health Risks of 6PPD and 6PPDQ: Assessment and Implications

6PPD和6PPD醌的环境与人类健康风险：评估与启示

https://www.mdpi.com/2305-6304/13/10/873

Zhang, S.; Tang, J.; Qiu, Z.; Huo, X.; Dong, L.; Zeng, X. Environmental and Human Health Risks of 6PPD and 6PPDQ: Assessment and Implications. Toxics 2025, 13(10), 873. https://doi.org/10.3390/toxics13100873

Toxics 期刊介绍

期刊名：Toxics (ISSN: 2305-6304)

主编：Demetrio Raldúa, IDAEA-CSIC, Spain

副主编：Xiaojun Luo, Chinese Academy of Sciences, China

期刊发表与有毒有害化学物质和材料相关的学术文章，主题范围涵盖毒理学、生态毒理学、环境科学、环境工程、环境化学和流行病学等学科。期刊已被Web of Science、PubMed和Scopus等多个数据库收录。目前期刊位于JCR毒理学一区和环境科学二区。

欢迎投稿：https://susy.mdpi.com/user/manuscripts/upload?form[journal_id]=171