论文标题：Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China

期刊： Frontiers of Medicine

作者：Dong Wei , Yusang Xie , Xuefei Liu , Rong Chen , Min Zhou , Xinxin Zhang, Jieming Qu

发表时间：15 Dec 2023

DOI：10.1007/s11684-023-1043-5

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导 读

上海交通大学医学院附属瑞金医院瞿介明等在Frontiers of Medicine发表综述论文《COVID-19病原体进化、防控策略及临床特征：来自中国的经验》(Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China)。本文系统回顾了新冠病毒从原型到奥密克戎变异株的进化与传播、中国新冠防控四阶段策略、患者临床特征及多种治疗手段，有助于合理评估公共卫生管理策略、推动疫苗和药物研发，为未来应对新冠病毒及其他病毒公共卫生事件提供参考。

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported at the end of 2019 as a worldwide health concern causing a pandemic of unusual viral pneumonia and many other organ damages, which was defined by the World Health Organization as coronavirus disease 2019 (COVID-19). The pandemic is considered a significant threat to global public health till now. In this review, we have summarized the lessons learnt during the emergence and spread of SARS-CoV-2, including its prototype and variants. The overall clinical features of variants of concern (VOC), heterogeneity in the clinical manifestations, radiology and pathology of COVID-19 patients are also discussed, along with advances in therapeutic agents.

2019年末，严重急性呼吸综合征冠状病毒2（SARS-CoV-2，简称新冠病毒）被报道。它引发了全球性的健康问题，导致了一场非典型病毒性肺炎的大流行，并造成患者许多其他器官的损伤。世界卫生组织将其定义为新冠病毒病（COVID-19）。迄今为止，这场大流行仍被视为对全球公共卫生的重大威胁。本文总结了在SARS-CoV-2出现和传播过程中所积累的经验教训，包括其原型毒株和变异株。同时，还讨论了关切变异株（VOC）的总体临床特征、COVID-19患者临床表现的异质性、影像学和病理学特征，以及治疗药物的进展。

期刊介绍

Frontiers of Medicine专注于发表临床医学和基础医学领域的最新研究成果，旨在通过全球医疗专业人员之间的交流促进健康和医疗保健的发展。该刊采用严格的同行评审和编辑流程，确保发表的文章的科学准确性、新颖性和重要性。

原文信息

标题

Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China

作者

Dong Wei¹, Yusang Xie^2,3,4, Xuefei Liu^2,3,4, Rong Chen^2,3,4, Min Zhou^2,3,4, Xinxin Zhang¹, Jieming Qu^2,3,4

机构

1. Department of Infectious Diseases, Research Laboratory of Clinical Virology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

2. Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

3. Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

4. Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases, Shanghai 200025, China

通讯作者

Jieming Qu

引用这篇文章

Dong Wei, Yusang Xie, Xuefei Liu, Rong Chen, Min Zhou, Xinxin Zhang, Jieming Qu. Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China. Front. Med., 2023, 17(6): 1030–1046 https://doi.org/10.1007/s11684-023-1043-5

https://journal.hep.com.cn/fmd/EN/10.1007/s11684-023-1043-5

https://link.springer.com/article/10.1007/s11684-023-1043-5

感谢作者对Frontiers of Medicine的信任和支持。

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