论文标题：Liver cell therapies: cellular sources and grafting strategies

期刊： Frontiers of Medicine

作者：Wencheng Zhang, Yangyang Cui, Yuan Du, Yong Yang, Ting Fang, Fengfeng Lu, Weixia Kong, Canjun Xiao, Jun Shi, Lola M. Reid, Zhiying He

发表时间：15 Jun 2023

DOI：10.1007/s11684-023-1002-1

微信链接：点击此处阅读微信文章

导 读

北卡罗来纳大学医学院Lola M. Reid博士和同济大学生命科学与技术学院何志颖研究员等在Frontiers of Medicine发表综述论文《肝细胞疗法：细胞来源与移植策略》（Liver cell therapies: cellular sources and grafting strategies）。本综述梳理了不同条件下参与肝脏修复的细胞的最新研究进展，旨在为终末期肝病提供有效的干预措施。

The liver has a complex cellular composition and a remarkable regenerative capacity. The primary cell types in the liver are two parenchymal cell populations, hepatocytes and cholangiocytes, that perform most of the functions of the liver and that are helped through interactions with non-parenchymal cell types comprising stellate cells, endothelia and various hemopoietic cell populations. The regulation of the cells in the liver is mediated by an insoluble complex of proteins and carbohydrates, the extracellular matrix, working synergistically with soluble paracrine and systemic signals. In recent years, with the rapid development of genetic sequencing technologies, research on the liver’s cellular composition and its regulatory mechanisms during various conditions has been extensively explored. Meanwhile breakthroughs in strategies for cell transplantation are enabling a future in which there can be a rescue of patients with end-stage liver diseases, offering potential solutions to the chronic shortage of livers and alternatives to liver transplantation. This review will focus on the cellular mechanisms of liver homeostasis and how to select ideal sources of cells to be transplanted to achieve liver regeneration and repair. Recent advances are summarized for promoting the treatment of end-stage liver diseases by forms of cell transplantation that now include grafting strategies.

肝脏具有复杂的细胞组成和卓越的再生能力。肝脏中的主要细胞类型为两种实质细胞群，即肝细胞和胆管细胞，它们承担了肝脏的大部分功能，并通过与非实质细胞（包括星状细胞、内皮细胞和各种造血细胞群）的相互作用发挥协同作用。肝脏细胞的调控由蛋白质和碳水化合物构成的不溶性复合物——细胞外基质介导，并与可溶性旁分泌信号和全身信号协同作用。近年来，随着基因测序技术的快速发展，关于肝脏细胞组成及其在不同状态下调控机制的研究得到了广泛探索。同时，细胞移植策略取得突破，为挽救终末期肝病患者带来了希望，为解决肝脏长期短缺问题提供了潜在解决方案，并有望成为肝移植的替代方法。本文将重点探讨肝脏稳态的细胞机制，以及如何选择理想的移植细胞来源以实现肝脏再生和修复。本文还总结了通过细胞移植（包括移植策略）促进终末期肝病治疗的最新进展。

期刊介绍

Frontiers of Medicine专注于发表临床医学和基础医学领域的最新研究成果，旨在通过全球医疗专业人员之间的交流促进健康和医疗保健的发展。该刊采用严格的同行评审和编辑流程，确保发表的文章的科学准确性、新颖性和重要性。

原文信息

标题

Liver cell therapies: cellular sources and grafting strategies

作者

Wencheng Zhang^1,2,3, Yangyang Cui^1,2,3,4, Yuan Du^1,5, Yong Yang^1,5, Ting Fang^1,2,3, Fengfeng Lu^1,2,3, Weixia Kong⁶, Canjun Xiao⁷, Jun Shi^5,7, Lola M. Reid⁸, Zhiying He^1,2,3

机构

1. Institute for Regenerative Medicine, Ji’an Hospital, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200123, China

2. Shanghai Engineering Research Center of Stem Cells Translational Medicine, Shanghai 200335, China

3. Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai 200120, China

4. Postgraduate Training Base of Shanghai East Hospital, Jinzhou Medical University, Jinzhou 121001, China

5. The First Affiliated Hospital of Nanchang University, Nanchang 330006, China

6. Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, 565-0871, Japan

7. Department of General Surgery, Ji’an Hospital, Shanghai East Hospital, School of Medicine, Tongji University, Ji’an 343006, China

8. Department of Cell Biology and Physiology and Program in Molecular Biology and Biotechnology; UNC School of Medicine, Chapel Hill, NC 27599, USA

通讯作者

Lola M. Reid, Zhiying He

引用这篇文章

Wencheng Zhang, Yangyang Cui, Yuan Du, Yong Yang, Ting Fang, Fengfeng Lu, Weixia Kong, Canjun Xiao, Jun Shi, Lola M. Reid, Zhiying He. Liver cell therapies: cellular sources and grafting strategies. Front. Med., 2023, 17(3): 432–457 https://doi.org/10.1007/s11684-023-1002-1

https://journal.hep.com.cn/fmd/EN/10.1007/s11684-023-1002-1

https://link.springer.com/article/10.1007/s11684-023-1002-1

感谢作者对Frontiers of Medicine的信任和支持。

《前沿》系列英文学术期刊

由教育部主管、高等教育出版社主办的《前沿》（Frontiers）系列英文学术期刊，于2006年正式创刊，以网络版和印刷版向全球发行。系列期刊包括基础科学、生命科学、工程技术和人文社会科学四个主题，是我国覆盖学科最广泛的英文学术期刊群，其中12种被SCI收录，其他也被A&HCI、Ei、MEDLINE或相应学科国际权威检索系统收录，具有一定的国际学术影响力。系列期刊采用在线优先出版方式，保证文章以最快速度发表。

中国学术前沿期刊网

http://journal.hep.com.cn