论文标题：Interval breast cancer is associated with other types of tumors

期刊：Nature Communications

作者：Felix Grassmann, Wei He et.al

发表时间：2019/10/22

数字识别码： 10.1038/s41467-019-12652-1

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《自然-通讯》本周发表的一篇论文Interval breast cancer is associated with other types of tumors指出，在两次常规筛查间隔期发现乳腺癌（间期癌）的患者罹患其他癌症的风险更高，报告多发癌家族史的可能性也更高。这一结果或为癌症预防方案的实施提供新的指南。

图1：间期乳腺癌风险中的癌症遗传风险评分。 图源：Grassmann等

间期乳腺癌的肿瘤一般较大，转移性较高。这种肿瘤更具侵袭性，预后也比筛查发现的肿瘤要差。

瑞典斯德哥尔摩卡罗林斯卡学院的Felix Grassmann和同事分析了两项瑞典研究和一项美国研究收集的数据，一共囊括了14846名乳腺癌患者，其中1772例为间期乳腺癌。作者发现，间期乳腺癌患者在确诊前后被诊断出其他癌症的可能性更大，如肺癌、结肠癌和皮肤癌。被诊断有其他癌症的间期乳腺癌患者报告多发癌家族史的比例是没有间期癌患者的三倍，这表明遗传性罕见突变或在其中起到了一定作用。

将以上研究结果纳入考虑范围，或能帮助更新现行的癌症预防方案，比如对特定人群进行补筛，提高乳腺间期癌幸存者和她们亲属的意识。作者认为有必要展开后续研究，进一步阐明哪些具体罕见突变与乳腺间期癌和多发性肿瘤有关。

摘要：Breast cancer (BC) patients diagnosed between two screenings (interval cancers) are more likely than screen-detected patients to carry rare deleterious mutations in cancer genes potentially leading to increased risk for other non-breast cancer (non-BC) tumors. In this study, we include 14,846 women diagnosed with BC of which 1,772 are interval and 13,074 screen-detected. Compared to women with screen-detected cancers, interval breast cancer patients are more likely to have a non-BC tumor before (Odds ratio (OR): 1.43 [1.19–1.70], P = 9.4 x 10−5) and after (OR: 1.28 [1.14–1.44], P = 4.70 x 10−5) breast cancer diagnosis, are more likely to report a family history of non-BC tumors and have a lower genetic risk score based on common variants for non-BC tumors. In conclusion, interval breast cancer is associated with other tumors and common cancer variants are unlikely to be responsible for this association. These findings could have implications for future screening and prevention programs.

（来源：科学网）