直播时间：2023年7月14日（周五）20:00-21:30

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北京时间2023年7月14日晚八点，iCANX Talks 第152期邀请到洛桑联邦理工学院 Francesco Stellacci 教授分享开发广谱抗病毒药物方面长达十余年的努力！更多精彩，敬请期待！

【嘉宾介绍】

Francesco Stellacci

Ecole Polytechnique Fédérale de LausanneSymmetry

Supramolecular Broad-Spectrum Antivirals

【Abstract】

Viral infections are a great threat for modern society, there are thousands of people that die every year because of them (mostly in under-developed countries) and many more have a lower quality of life because of them. Furthermore, it is become apparent that pandemic infection can have enormous consequences on global health as well as on the economy of the entire world.

病毒感染对于现代社会是巨大的威胁，每一年有数以千计的人因此致死（大多数发生在欠发达国家），更多的人由于病毒感染生活质量降低。此外，瘟疫感染对于整个世界的卫生以及经济可以造成极为严重的后果。

In this talk I will summarize a decade-long effort in my laboratory to develop broad-spectrum antivirals. The approach that will be presented is different from most biological approach as it is focused on an extracellular mechanism that affect the structural integrity of the virus rendering them non infective irreversibly. I will discuss the development of the compounds that we are investigating and their putative mechanism. In vitro, ex vivo, and in vivo example of the efficacy of such compounds will be discussed.

在本次讲座中我会总结我们实验室在开发广谱抗病毒药物方面长达十余年的努力。我将要介绍的方法与大多数生物方法不同，因为它专注于影响病毒结构完整性的细胞外机制，使它们不可逆地不具有感染性。我将讨论我们正在研究的化合物的开发及其假定的机制和这些化合物在体外、体内和离体的疗效实例。

【BIOGRAPHY】

Prof. Francesco Stellacci got his degree in Materials Engineering at the Politecnico di Milano in 1998 with Prof. Zerbi. He then moved as a post-doc with Prof. J.W. Perry in the Department of Chemistry at the University of Arizona. In 2002 he became as assistant professor in the Department of Materials Science and Engineering at MIT (Cambridge, USA). There he became associate professor with tenure in 2009. In 2010, he moved as a full professor to EPFL where he holds the Constellium chair. Stellacci has published more than 130 papers and has more than 15 patent applications. He has won numerous awards, among the the Technology Review TR35 ’top innovator under 35’, the Popular Science Magazine ’Brilliant 10’, and the EMRS EU40. He is a Fellow of the Royal Society of Chemistry, of the Global Young Academy, and of the European Academy of Sciences.

Francesco Stellacci教授于1998年在米兰理工大学获得材料工程学位，师从Zerbi教授。他随后在亚利桑那大学化学系J. W. Perry教授课题组进行博士后研究。在2002年他成为麻省理工学院材料科学与工程系助理教授（位于美国剑桥）。此后他于2009年成为副教授并获得终身教职。在2010年，他成为EPFL全职教授，并担任Constellium主席。Stellacci已经发表了130多篇论文，并有超过15项专利申请。他赢得了许多奖项，其中包括《技术评论》TR35"35岁以下的顶级创新者"，《大众科学》杂志 "辉煌10人"，以及EMRS EU40。他是皇家化学学会、全球青年学院和欧洲科学院的院士。