期刊名：BioChem

期刊主页：https://www.mdpi.com/journal/biochem

近年来，生物医学研究的突破愈发依赖从分子机制到临床转化的跨尺度创新。本专题汇集BioChem期刊系列成果，系统勾勒了这一广阔图景。在分子层面，研究聚焦于富含亮氨酸重复序列的超二级结构、多金属氧酸盐治疗阿尔茨海默病的潜力，以及黄酮类二聚体靶向癌症标志物的新策略。技术与方法方面，涵盖代谢组学生物信息学、基因–药物–疾病知识图谱构建、质量源于设计（QbD）指导的口服控释片开发，以及靶向氧化应激与炎症的治疗综述。临床转化层面涉及儿童卵巢肿瘤病理、香兰素代谢工程生产、乳酸菌从生物加工到纳米医学的应用、精油抗结肠癌的微纳载体设计，以及人工智能驱动的个性化癌症疫苗开发。此外，补充研究关注黄酮类纳米颗粒在关节炎治疗、老年患者非甾体抗炎药合理使用、iPSC心肌细胞线粒体成熟及植物提取物水凝胶制备等热点。全文收录16篇文献，共同描绘从基础机制到精准干预的创新路径。欢迎访问文章网页深入阅读，期待与学界同仁共话前沿进展！

1. Multiple Super-Secondary Structures in Leucine-Rich Repeats with Dual Characteristics

富含亮氨酸重复序列中具有双重特征的多种超二级结构

http://www.mdpi.com/2673-6411/6/3/15

Matsushima, N.; Batkhishig, D.; Enkhbayar, P. Multiple Super-Secondary Structures in Leucine-Rich Repeats with Dual Characteristics. BioChem 2026, 6, 15.

2. Multi-Relational Knowledge Graph for Drug Repurposing and Side-Effect Burden Prediction Using Gene–Drug–Disease Associations

基于基因–药物–疾病关联的多关系知识图谱用于药物重定位及副作用负担预测

http://www.mdpi.com/2673-6411/6/2/13

Sharmin, A.; Mahmud, B.U. Multi-Relational Knowledge Graph for Drug Repurposing and Side-Effect Burden Prediction Using Gene–Drug–Disease Associations. BioChem 2026, 6, 13.

3. Paediatric Ovarian Neoplasms: Histopathological, Molecular, and Translational Perspectives

儿童卵巢肿瘤：组织病理学、分子及转化医学视角

http://www.mdpi.com/2673-6411/6/1/5

Marzullo, A.; Salzillo, C. Paediatric Ovarian Neoplasms: Histopathological, Molecular, and Translational Perspectives. BioChem 2026, 6, 5.

4. Lactic Acid Bacteria: From Bioprocessing to Nanomedicine

乳酸菌：从生物加工到纳米医学

http://www.mdpi.com/2673-6411/6/1/3

Rezvani, M.; Manconi, M.; Düzgüne?, N. Lactic Acid Bacteria: From Bioprocessing to Nanomedicine. BioChem 2026, 6, 3.

5. Polyoxometalates Progress for the Treatment of Alzheimers Disease

多金属氧酸盐在阿尔茨海默病治疗中的研究进展

https://www.mdpi.com/2673-6411/5/4/41

Aureliano, M.; Mateus, J.; Rijo, D.M. Polyoxometalates’ Progress for the Treatment of Alzheimer’s Disease. BioChem 2025, 5, 41.

6. Therapeutic Strategies Targeting Oxidative Stress and Inflammation: A Narrative Review

靶向氧化应激和炎症的治疗策略：一项叙述性综述

https://www.mdpi.com/2673-6411/5/4/35

Manful, C.F.; Fordjour, E.; Ikumoinein, E.; Abbey, L.; Thomas, R. Therapeutic Strategies Targeting Oxidative Stress and Inflammation: A Narrative Review. BioChem 2025, 5, 35.

7. Therapeutic Potential of Essential Oils and Their Bioactive Compounds Against Colon Cancer: Focus on Colon-Specific Micro- and Nanocarriers

精油及其生物活性化合物对抗结肠癌的治疗潜力：聚焦结肠特异性微纳载体

http://www.mdpi.com/2673-6411/5/3/26

Gvozdeva, Y.; Georgieva, P. Therapeutic Potential of Essential Oils and Their Bioactive Compounds Against Colon Cancer: Focus on Colon-Specific Micro- and Nanocarriers. BioChem 2025, 5, 26.

8. Enhancing Mitochondrial Maturation in iPSC-DerivedCardiomyocytes: Strategies for Metabolic Optimization

促进iPSC衍生心肌细胞线粒体成熟：代谢优化策略

http://www.mdpi.com/2673-6411/5/3/23

Shahannaz, D.C.; Sugiura, T.; Ferrell, B.E. Enhancing Mitochondrial Maturation in iPSC-DerivedCardiomyocytes: Strategies for Metabolic Optimization. BioChem 2025, 5, 23.

9. Advances in Oral Solid Drug Delivery Systems: Quality by Design Approach in Development of Controlled Release Tablets

口服固体给药系统进展：基于质量源于设计（QbD）理念的控释片剂开发

http://www.mdpi.com/2673-6411/5/2/9

Atre, P.; Rizvi, S.A.A. Advances in Oral Solid Drug Delivery Systems: Quality by Design Approach in Development of Controlled Release Tablets. BioChem 2025, 5, 9.

10. Advances in Personalized Cancer Vaccine Development: AI Applications from Neoantigen Discovery to mRNA Formulation

个性化癌症疫苗开发进展：从新抗原发现到mRNA制剂中的人工智能应用

https://www.mdpi.com/2673-6411/5/2/5

Kong, H. Advances in Personalized Cancer Vaccine Development: AI Applications from Neoantigen Discovery to mRNA Formulation. BioChem 2025, 5, 5.

11. An Overview of the Therapeutic Potential of Dimeric Flavonoids for Targeting Cancer Hallmarks

二聚体黄酮类化合物靶向癌症标志物的治疗潜力概述

http://www.mdpi.com/2673-6411/5/1/2

Lopes, I.; Meireles, I.; Rocha, R.; Medeiros, R.; Cerqueira, F. An Overview of the Therapeutic Potential of Dimeric Flavonoids for Targeting Cancer Hallmarks. BioChem 2025, 5, 2.

12. Biotechnological Advances in Vanillin Production: From Natural Vanilla to Metabolic Engineering Platforms

香兰素生产的生物技术进展：从天然香兰到代谢工程平台

http://www.mdpi.com/2673-6411/4/4/17

Tazon, A.W.; Awwad, F.; Meddeb-Mouelhi, F.; Desgagné-Penix, I. Biotechnological Advances in Vanillin Production: From Natural Vanilla to Metabolic Engineering Platforms. BioChem 2024, 4, 323–349.

13. Appropriate Prescription of Non-Steroidal Anti-Inflammatory Drugs in Geriatric Patients—A Systematic Review

老年患者非甾体抗炎药的合理处方—一项系统评价

https://www.mdpi.com/2673-6411/4/4/15

Costa, C.; Soares, D.; Borges, A.; Gonçalves, A.; Andrade, J.P.; Ribeiro, H. Appropriate Prescription of Non-Steroidal Anti-Inflammatory Drugs in Geriatric Patients—A Systematic Review. BioChem 2024, 4, 300–312.

14. Evaluation of Antioxidant, Antibacterial and Enzyme-Inhibitory Properties of Dittany and Thyme Extracts and Their Application in Hydrogel Preparation

岩黄蒿与百里香提取物的抗氧化、抗菌及酶抑制活性评价及其在水凝胶制备中的应用

http://www.mdpi.com/2673-6411/4/3/9

Spyrou, S.; Bellou, M.G.; Papanikolaou, A.; Nakou, K.; Kontogianni, V.G.; Chatzikonstantinou, A.V.; Stamatis, H. Evaluation of Antioxidant, Antibacterial and Enzyme-Inhibitory Properties of Dittany and Thyme Extracts and Their Application in Hydrogel Preparation. BioChem 2024, 4, 166–188.

15. Bioinformatic Analysis of Metabolomic Data: From Raw Spectra to Biological Insight

代谢组学数据的生物信息学分析：从原始质谱到生物学见解

https://www.mdpi.com/2673-6411/4/2/5

Santamaria, G.; Pinto, F.R. Bioinformatic Analysis of Metabolomic Data: From Raw Spectra to Biological Insight. BioChem 2024, 4, 90–114.

16. Flavonoids and Flavonoid-Based Nanoparticles for Osteoarthritis and Rheumatoid Arthritis Management

黄酮类化合物及基于黄酮类化合物的纳米颗粒用于骨关节炎和类风湿关节炎的管理

https://www.mdpi.com/2673-6411/4/1/3

Wahnou, H.; Limami, Y.; Oudghiri, M. Flavonoids and Flavonoid-Based Nanoparticles for Osteoarthritis and Rheumatoid Arthritis Management. BioChem 2024, 4, 38–61.

期刊介绍

主编：马步勇教授，上海交通大学，中国

BioChem (ISSN 2673-6411) 是一本国际性、跨学科的开放获取期刊，涵盖分子生物学、细胞生物学、结构生物学、核酸生物学、化学生物学、合成生物学、疾病生物学、生物物理学及理论生物化学等领域。期刊已被 ESCI (Web of Science), Scopus, EBSCO等数据库收录。

2025 Impact Factor：/

2025 CiteScore：2.9

Time to First Decision：26.4 Days

Acceptance to Publication：5.8 Days