2026年8月19日，澳大利亚莫纳什大学心理科学学院特纳脑与心理健康研究所Devon Stoliker等合作在《自然》上发表研究，揭示了迷幻药裸盖菇素（psilocybin）并非简单扰乱大脑活动，而是将大脑活动重组为与情境和主观体验相协调的结构化模式。

迷幻药可通过重组大脑连接性深刻改变意识，产生塑造持久心理改变的急性体验。迷幻药动力学通常被描述为去同步化或熵增的无序状态，但支撑参与者常报告的自我消解和边界消解体验的大脑组织方式，以及情境如何塑造这种组织，仍未得到解决。为此，研究人员获取了迄今最大规模的单中心迷幻药神经影像数据集。62名成年人在服用裸盖菇素前及服药当天（fMRI约给药后80分钟；EEG约给药后150分钟），分别在静息状态和自然刺激（冥想、音乐和电影）下接受了功能性磁共振成像（fMRI）和脑电图（EEG）扫描。其中半数参与者将此体验评为其一生中最有意义的经历之一。在此，研究人员利用机器学习将每个个体的大脑动力学表示为低维轨迹，发现裸盖菇素将大脑活动重组为结构化的、情境敏感的模式，这些模式与主观体验的质量共变，揭示了过去时间平均测量所遗漏的潜在有序性。通常分隔内部和外部处理的网络发生了整合，在那些报告感受到与环境连续而非分离的体验（研究人员称之为“嵌入性”状态）的参与者中，产生了连贯的、情境对齐的轨迹。这种情境对齐的强度与自我消解和边界消解体验的深度以及次日心态变化均呈正相关。

研究人员的发现将表观上的无序重新定义为与情境对齐的潜在组织，将神经生物学与主观体验和行为改变联系起来。

附：英文原文

Title: Psychedelics align brain activity with context

Author: Stoliker, Devon, Novelli, Leonardo, Khajehnejad, Moein, Biabani, Mana, Greaves, Matthew D., Barta, Tamrin, Williams, Martin, Chopra, Sidhant, Bazin, Olivier, Simonsson, Otto, Chambers, Richard, Barrett, Frederick S., Deco, Gustavo, Preller, Katrin H., Carhart-Harris, Robin L., Seth, Anil K., Sundram, Suresh, Egan, Gary F., Razi, Adeel

Issue&Volume: 2026-08-19

Abstract: Psychedelics can profoundly alter consciousness by reorganizing brain connectivity, producing acute experiences that shape lasting psychological change. Psychedelic dynamics are commonly described as desynchronized or entropically disordered, yet the brain organization underlying self-dissolving and boundary-dissolving experiences that participants often report, and how context shapes that organization, remain unresolved. To address this, we acquired the largest single-site psychedelic neuroimaging dataset to date. Sixty-two adults underwent functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) during rest and naturalistic stimuli (meditation, music and movie), before and on the day of psilocybin administration (fMRI ~80min post-dose; EEG ~150min post-dose). Half ranked the experience among the most meaningful of their lives. Here, using machine learning to represent the brain dynamics of each individual as low-dimensional trajectories, we show that psilocybin reorganizes brain activity into structured, context-sensitive patterns that co-vary with the quality of subjective experience, revealing a latent order missed by time-averaged measures. Networks that ordinarily segregate internal and external processing integrated, producing cohesive context-aligned trajectories in participants reporting the felt experience of being continuous with, rather than separate from, the environment, a state we refer to as embeddedness. The strength of this context alignment scaled with both the depth of self-dissolving and boundary-dissolving experience and the next-day mindset change. Our findings recast apparent disorder as latent organization aligned with context, linking neurobiology to subjective experience and behavioural change.

DOI: 10.1038/s41586-026-10910-z

Source: https://www.nature.com/articles/s41586-026-10910-z