在这项研究中，该课题组比较了金黄色念珠菌和白色念珠菌在小鼠皮肤上的定植，以阐明不同的真菌-免疫相互作用。金黄色葡萄球菌表现出增强的皮肤持久性、毛囊亲和性和直接头发粘附性。白色念珠菌触发3/17型偏斜的杀菌抗真菌免疫应答，耳念珠菌触发1型干扰素-γ (IFNγ)驱动的直接针对毛囊的应答。IFNγ通过向角质形成细胞发送信号和抑制上皮抗真菌防御程序来增强金黄色葡萄球菌的定植。遗传和生化方法表明，在与皮肤相关的线索的反应中，金黄色葡萄球菌增加细胞壁几丁质暴露，触发1型免疫并促进真菌的持久性。
据介绍，耳念珠菌是一种多重耐药真菌，引起重大公共卫生关注，其在皮肤上持续存在的机制（致命疫情的主要风险因素）尚不清楚。
附：英文原文
Title: The fungal pathogen Candida auris exposes chitin to trigger IFNγ and persist in hair follicles
Author: Eric Dean Merrill, Victoria Prudent, Pauline Basso, Emilie Rapp, Parna Moghadam, Abram Rodriguez, Ethan Hung, Charlotte Hurabielle, Jeffrey Cheng, Raymond Jaihyun Cho, Brook Abegaze, Amanda Buck, Kennedi Pyper, Alessandra Veinbachs, Elina K. C. Wells, Tiffany C. Scharschmidt, Michael D. Rosenblum, Ari B. Molofsky, Suzanne M. Noble
Issue&Volume: 2026-08-06
Abstract: Candida auris is a multidrug-resistant fungus of major public health concern whose mechanisms for persistence on skin, a major risk factor for deadly outbreaks, remain unclear. In this study, we compared skin colonization by C. auris versus C. albicans to illuminate distinct fungal-immune interactions in mice. C. auris exhibited enhanced skin persistence, hair follicle tropism, and direct hair binding. Whereas C. albicans triggered a type 3/17–skewed sterilizing antifungal immune response, C. auris triggered a type 1 interferon-γ (IFNγ)–driven response directed toward hair follicles. IFNγ enhanced C. auris colonization by signaling to keratinocytes and repressing epithelial antifungal defense programs. Genetic and biochemical approaches demonstrated that, in response to cues associated with the skin, C. auris increases cell wall chitin exposure, triggering type 1 immunity and promoting fungal persistence.
DOI: adu6688
Source: https://www.science.org/doi/10.1126/science.adu6688