近日，东北师范大学胡俊丽团队报道了全水相介质中热振荡绿色制备高强度丝素蛋白水凝胶。2026年7月2日出版的《中国高分子科学杂志》发表了这项成果。

丝素蛋白水凝胶在生物医学应用中往往力学强度不足。传统的增强策略通常依赖有毒交联剂或不可降解组分，从而牺牲了生物相容性和生物可降解性。近年来出现的基于有机溶剂的方法虽有进步，但其环境毒性仍令人担忧。

研究组提出了一种新颖的热振荡策略，仅由全水相丝素蛋白溶液制备高强度丝素蛋白水凝胶，无需使用有毒化学品或不可降解材料。所得水凝胶表现出优异的力学性能：拉伸强度达2.6 MPa，断裂伸长率为152.6%，韧性为3.0 MJ/m³，不仅超越了有机溶剂衍生的丝素蛋白水凝胶，而且可与双交联、双网络或复合体系相媲美。该丝素蛋白水凝胶还具有极低的溶胀率、出色的长期完整性和优异的生物相容性。这种强韧、生物相容且可生物降解的丝素蛋白水凝胶在承重组织支架、长期植入式药物递送系统和耐用伤口敷料等生物医学应用中前景广阔。

附：英文原文

Title: Green Fabrication of High-strength Silk Fibroin Hydrogels <italic style="font-style: italic">via</italic> Thermal Oscillation in All-aqueous Media

Author: Yu-Si Long, Mei-Yi Lu, Jia-Wei Qi, Geng Chen, Yu Sun, Xiu-Xia He, Tian-Hui Zhang, Li-Guo Cui, Jun-Li Hu, Yi-Chun Liu

Issue&Volume: 2026-07-02

Abstract: Silk fibroin hydrogels frequently exhibit insufficient mechanical strength for biomedical applications. Conventional enhancement strategies often rely on toxic crosslinkers or nondegradable components, thereby compromising biocompatibility and biodegradability. Recently emerged organic solvent-based methods represent an advance, but their associated environmental toxicity remains a concern. In this work, we present a novel thermal oscillation strategy for fabricating high-strength silk fibroin hydrogels exclusively from all-aqueous silk fibroin solutions, eliminating the need for toxic chemicals or non-degradable materials. The resulting hydrogels exhibit outstanding mechanical properties, tensile strength of 2.6 MPa, elongation rate of 152.6%, and toughness of 3.0 MJ/m3, which not only surpass the organic solvent-derived silk fibroin hydrogels but also rival the dual-crosslinked, double-networked or composite systems. The silk fibroin hydrogels also exhibit a minimal swelling ratio, outstanding long-term integrity, and excellent biocompatibility. The robust, biocompatible, and biodegradable silk fibroin hydrogels are promising for biomedical applications such as load-bearing tissue scaffolds, long-term implantable drug delivery systems, and durable wound dressings.

DOI: 10.1007/s10118-026-3645-2

Source: https://www.cjps.org/en/article/doi/10.1007/s10118-026-3645-2/