期刊名： Pharmaceutics

期刊主页：https://www.mdpi.com/journal/pharmaceutics

为同步核酸递送领域最新研究进展，Pharmaceutics特此汇总展示 2025 年度相关精选论文。

本次精选论文聚焦核酸递送方向，涵盖信使 RNA、小干扰 RNA、微小 RNA 及质粒 DNA 递送体系、非病毒递送载体、靶向递送策略、制剂稳定性优化，同时收录核酸药物临床前疗效探究与递送机制相关研究。

愿这些前沿研究能为您带来启发。

1.Predictive Lung- and Spleen-Targeted mRNA Delivery with Biodegradable Ionizable Lipids in Four-Component LNPs

基于四组分脂质纳米颗粒（LNP）及可生物降解可电离脂质的肺脾靶向预测性mRNA递送

https://www.mdpi.com/1999-4923/17/4/459

Heredero, J.; Peña, Á.; Broset, E.; Blandín, B.; de Miguel, D.; Alejo, T.; Toro, A.; Mata, E.; López-Gavín, A.; Gallego-Lleyda, A.; et al. Predictive Lung- and Spleen-Targeted mRNA Delivery with Biodegradable Ionizable Lipids in Four-Component LNPs. Pharmaceutics 2025, 17, 459.

2.Targeting the Eye: RNA-Based Therapies, Interferences, and Delivery Strategies

靶向眼部：基于RNA的疗法、干扰技术及递送策略

https://www.mdpi.com/1999-4923/17/10/1326

Hassan, M.S.A.-R.; Zhong, C.; Hassan, F.; Li, S.K. Targeting the Eye: RNA-Based Therapies, Interferences, and Delivery Strategies. Pharmaceutics 2025, 17, 1326.

3.Microfluidic Optimization of PEI-Lipid Hybrid Nanoparticles for Efficient DNA Delivery and Transgene Expression

用于高效DNA递送与转基因表达的PEI-脂质杂化纳米颗粒的微流控优化

https://www.mdpi.com/1999-4923/17/4/454

Hosseini-Kharat, M.; Wignall, A.; Mekonnen, Z.A.; Ung, B.S.-Y.; Chereda, B.; Bremmell, K.E.; Grubor-Bauk, B.; Prestidge, C.A. Microfluidic Optimization of PEI-Lipid Hybrid Nanoparticles for Efficient DNA Delivery and Transgene Expression. Pharmaceutics 2025, 17, 454.

4.Targeted Delivery of VEGF-siRNA to Glioblastoma Using Orientation-Controlled Anti-PD-L1 Antibody-Modified Lipid Nanoparticles

利用取向可控的抗PD-L1抗体修饰脂质纳米颗粒实现VEGF-siRNA对胶质母细胞瘤的靶向递送

https://www.mdpi.com/1999-4923/17/10/1298

Matsuo-Tani, A.; Matsumoto, M.; Hiu, T.; Kamiya, M.; Geng, L.; Takayama, R.; Ushiroda, Y.; Kato, N.; Nakamura, H.; Yoshida, M.; et al. Targeted Delivery of VEGF-siRNA to Glioblastoma Using Orientation-Controlled Anti-PD-L1 Antibody-Modified Lipid Nanoparticles. Pharmaceutics 2025, 17, 1298.

5.MicroRNA-Based Delivery Systems for Chronic Neuropathic Pain Treatment in Dorsal Root Ganglion

背根神经节中用于慢性神经病理性疼痛治疗的微小 RNA 递送体系

https://www.mdpi.com/1999-4923/17/7/930

Jackson, S.; Gigliobianco, M.R.; Casadidio, C.; Di Martino, P.; Censi, R. MicroRNA-Based Delivery Systems for Chronic Neuropathic Pain Treatment in Dorsal Root Ganglion. Pharmaceutics 2025, 17, 930.

6.Examining the Impact of Storage Conditions on the Stability of a Liquid Formulation of mRNA-Loaded Lipid Nanoparticles

考察储存条件对载mRNA脂质纳米颗粒液体制剂稳定性的影响

https://www.mdpi.com/1999-4923/17/9/1194

Sato, M.; Samaridou, E.; Beck-Broichsitter, M.; Maeki, M.; Kita, S.; Tokeshi, M.; Maenaka, K.; Harashima, H.; Sato, Y. Examining the Impact of Storage Conditions on the Stability of a Liquid Formulation of mRNA-Loaded Lipid Nanoparticles. Pharmaceutics 2025, 17, 1194.

7.Small Interfering RNA Carriers for Oncotherapy: A Preclinical Overview

用于肿瘤治疗的小干扰RNA载体：临床前综述

https://www.mdpi.com/1999-4923/17/11/1408

Aranda-Lara, L.; Escudero-Castellanos, A.; Trujillo-Nolasco, M.; Morales-Avila, E.; Ocampo-García, B.; Oros-Pantoja, R.; Sánchez-Monroy, V.; Isaac-Olivé, K. Small Interfering RNA Carriers for Oncotherapy: A Preclinical Overview. Pharmaceutics 2025, 17, 1408.

8.Emerging Approaches for the Discovery of Lipid-Based RNA Delivery Systems

脂质类 RNA 递送系统的新兴研发策略

https://www.mdpi.com/1999-4923/17/9/1231

Meers, P. Emerging Approaches for the Discovery of Lipid-Based RNA Delivery Systems. Pharmaceutics 2025, 17, 1231.

9.Synthesis of Terminal-Alkylated PEGs with Imine Spacer to Form Iminium Mono-Ion Complexes for pDNA Delivery into Skeletal Muscle

含亚胺间隔基端烷基化聚乙二醇的合成及其阳离子单离子复合物用于骨骼肌质粒 DNA 递送

https://www.mdpi.com/1999-4923/17/8/1054

Oba, R.; Endo-Takahashi, Y.; Negishi, Y.; Asayama, S. Synthesis of Terminal-Alkylated PEGs with Imine Spacer to Form Iminium Mono-Ion Complexes for pDNA Delivery into Skeletal Muscle. Pharmaceutics 2025, 17, 1054.

10.Lipid Nanoparticle-Mediated RNAi Against GIPC1 Overcomes Chemoresistance in Pancreatic Ductal Adenocarcinoma

脂质纳米颗粒介导 RNA 干扰靶向 GIPC1，克服胰腺导管腺癌化疗耐药

https://www.mdpi.com/1999-4923/17/10/1334

Madamsetty, V.S.; Rachamala, H.K.; Dutta, S.K.; Wang, E.; Pal, K.; Mukhopadhyay, D. Lipid Nanoparticle-Mediated RNAi Against GIPC1 Overcomes Chemoresistance in Pancreatic Ductal Adenocarcinoma. Pharmaceutics 2025, 17, 1334.

期刊介绍

主编：Patrick J. Sinko, Rutgers University, USA

期刊领域涵盖生物制药、药物递送、药物控释、药物制剂、药物靶向、药代动力学、纳米医学、药物遗传学、药物基因组学、药效学等。目前期刊已被SCIE、Scopus和PubMed等数据库收录。

2024 Impact Factor：6.9

2025 CiteScore：12.5

Time to First Decision：16.3 Days

Acceptance to Publication：3.3 Days