该课题组表明果蝇更喜欢有时间组织的生活。由于光诱导核心昼夜节律时钟蛋白的降解，持续的照明会使昼夜节律时钟停止并导致不规律的运动活动。当果蝇在恒定的光照环境中选择在黑暗和明亮的区域之间移动时，它们能够保持甚至恢复有节奏的行为模式。这些自我造成的节奏伴随着已知驱动行为节奏的时钟神经元中的分子节奏。与节律不规律的果蝇相比，行为节律性与睡眠质量的改善有关，这表明选择在生物钟控制下生活有直接的好处。
据了解，生物钟提供了适应性优势，使生物体能够调整其生理和行为以适应地球上日常环境的变化。
附：英文原文
Title: Fruit flies actively restart their circadian clock by proactively shaping their environment
Author: Angelica Coculla, Luis Garcia Rodriguez, Maite Ogueta, Ralf Stanewsky
Issue&Volume: 2026-07-02
Abstract: Circadian clocks provide adaptive advantages, enabling organisms to adjust their physiology and behavior to daily environmental changes on Earth. Here, we show that fruit flies prefer a temporally organized life. Because of light-induced degradation of the core circadian clock protein Timeless, constant illumination stops the circadian clock and leads to arrhythmic locomotor activity. When given the choice to move between dark and illuminated areas in a constant light environment, flies were able to maintain, or even regain, rhythmic behavioral patterns. These self-inflicted rhythms were accompanied by molecular rhythms in clock neurons known to drive behavioral rhythms. Behavioral rhythmicity was correlated with improved sleep quality compared with that of arrhythmic flies, demonstrating an immediate benefit of choosing to live under circadian clock control.
DOI: adw2239
Source: https://www.science.org/doi/10.1126/science.adw2239