该研究组展示了来自脊索动物、节肢动物和软体动物等27个物种的成人心脏的多组学图谱。联合分析表明，双侧动物的心脏共享一个核心基因库，采取逐步“附加”的方法作为一种普遍的进化策略。原心脏由关键的细胞类型组成，包括心肌细胞、成纤维细胞、内皮细胞和神经细胞，它们在随着生活环境的变化和心血管系统的相应适应而进化时保持着核心特征。此外，该课题组人员揭示了一种进化保守的心肌细胞状态动态，可能与心脏发育和应激反应有关。最后，研究人员确定了一个共同的分子程序，从心室基础上支持腔室进化。总之，这项工作为理解心脏进化的内在机制奠定了基础。
据悉，动物心脏在适应进化过程中呈现出不同的解剖结构。
附：英文原文
Title: Spatially resolved single-cell atlas reveals the macroevolutionary trajectory of animal hearts
Author: Shanshan Lian, Wei Wang, Yaoxin Liu, Meina Lu, Wentao Han, Jiaxin Luo, Xuejiao Zhang, Yue Pang, Yuru Li, Yufeng Li, Xin Dang, Peiyan Wang, Yating Qin, Ning Tan, Fang Zhang, Jin Zhang, Shuai Gao, Runyi Zhang, Lidong Guo, Lei Jiang, Pengchong Zhang, Yuehuan Zhang, Zhe Qu, Shanshan Pan, Yue Zhang, Naina Hu, Yadong Chen, Yun Cao, Wenbin Li, Xiaomei Chen, Junjie Shi, Shuaiqi Yang, Yiran Li, Qiuyun Song, Lisui Bao, Yuli Li, Xiawei Liu, Jing Wang, Lingling Zhang, Rui Li, Xin Yu, Tao Yang, Jing Chen, Ling Li, Mengqi Zhang, Lei Li, Ruihua Zhang, Hongyan Li, Ying Gu, Xun Xu, Huanming Yang, Zhenmin Bao, C. Geoffrey Burns, Caroline E. Burns, Robert G. Kelly, Jianxun Wang, Yang Zhao, Ying Su, Guangyi Fan, Qun Liu, Shi Wang, Ji-Feng Fei, Silin Pan, Long Zhao
Issue&Volume: 2026-07-23
Abstract: Animal hearts display diverse anatomical structures during adaptive evolution. Here, we present a multi-omics atlas of adult hearts from 27 species across chordates, arthropods, and mollusks. Joint analysis indicates that Bilateria hearts share a core gene repertoire, taking a stepwise “add-on” approach as a universal evolutionary strategy. The proto-heart is populated by key cell types, including cardiomyocytes, fibroblasts, endothelial, and neural cells, which maintained core signatures while evolving with shifts in living environments and corresponding adaptations in the cardiovascular system. Additionally, we reveal an evolutionarily conserved cardiomyocyte state dynamic potentially linked to cardiac development and stress responses. Finally, we identify a common molecular program underpinning chamber evolution from a ventricular foundation. Together, this work establishes a resource for understanding the intrinsic mechanisms of heart evolution.
DOI: adw0855
Source: https://www.science.org/doi/10.1126/science.adw0855