近日，暨南大学冉洋团队开发了用于肿瘤闭环光热治疗的多功能光纤治疗探头。这一研究成果于2026年4月27日发表在《光：科学与应用》杂志上。

光纤与光治疗诊断剂的结合，已成为应对光穿透深度有限及纳米材料全身毒性等挑战的一种有前景的策略。然而，光纤探头的多路复用潜力仍未得到充分重视，这导致了切口增大、重复的有创操作以及缺乏实时治疗反馈等问题。

研究组提出一种利用波分复用技术实现单光纤多功能集成的方案。作为概念验证，通过将激发波段互不重叠的pH指示剂、温度指示剂和光热剂共同固定在锥形光纤表面，他们开发出一种能够实现肿瘤光热疗法闭环治疗的光纤诊疗探针。治疗前，该探针可通过揭示肿瘤pH梯度来实现肿瘤边缘的识别。治疗中，光热剂可将光能转化为热能用于光热治疗，同时实时温度监测能够实现精准的热剂量控制。治疗后，通过实时监测酸性肿瘤微环境的逆转，可快速评估疗效。动物实验验证了该探针优异的治疗效果和生物相容性。这项研究为多功能光纤诊疗平台开辟了新途径，其中模块化波长分配可实现可定制的微创干预与反馈监测，在临床实践和机理探索方面均具有重要前景。

附：英文原文

Title: Multifunctional fiber-optic theranostic probe for closed-loop tumor photothermal therapy

Author: Li, Zesen, Li, Zhuoran, Cheng, Zhongyuan, Borri, Claudia, Giannetti, Ambra, Lan, Ni, Long, Junqiu, Chen, Wenwei, Cai, Xiangran, Yang, Jingge, Guan, Bai-Ou, Chiavaioli, Francesco, Ran, Yang

Issue&Volume: 2026-04-27

Abstract: The combination of optical fiber and phototheranostic agents has emerged as a promising strategy to address the challenges of limited light penetration depth and systemic toxicity of nanomaterials. However, the multiplexing potential of fiber-optic probes remains underrated, resulting in enlarged incisions, repeated invasive procedures, and a lack of real-time therapeutic feedback. Herein, we propose a scheme for singlefiber multifunctional integration leveraging wavelength division multiplexing technology. As a proof-of-concept, by co-immobilizing pH indicator, temperature indicator, and photothermal agent with non-overlapped excitation bands onto tapered optical fiber surface, a fiber-optic theranostic probe enabling closed-loop tumor photothermal therapy was developed. Pre-treatment, the probe can achieve tumor edge identification through revealing the tumor pH gradient. Intra-treatment, the photothermal agent can convert optical energy into heat for photothermal therapy, while simultaneous temperature monitoring enables precise thermal dose control. Post-treatment, rapid efficacy assessment can be achieved via real-time monitoring of the reversal of acidic tumor microenvironment. Animal experiments validate the excellent therapeutic efficacy and biocompatibility of the probe. This research opens new avenues for multifunctional fiber-optic theranostic platforms, where modular wavelength assignment enables customizable minimally invasive interventions and feedback monitoring, holding significant promise for both clinical practice and mechanistic exploration.

DOI: 10.1038/s41377-026-02219-3

Source: https://www.nature.com/articles/s41377-026-02219-3