麦吉尔大学李剑宇课题组的研究显示，工程化坚韧血凝块以实现快速止血与增强再生。2026年4月29日出版的《自然》杂志发表了这项成果。

在这里，研究小组报告了一种将红细胞快速交联成坚韧的细胞凝胶并将其整合到血凝块中的策略。由此产生的工程血凝块（EBCs）在几秒钟内形成，与天然血凝块相比，断裂韧性增加了13倍，粘附能提高了4倍。实验和模型确定机械集成细胞的断裂是关键的增韧机制。体内研究表明，EBCs可以快速止血，促进组织再生，减轻炎症和异物反应，防止术后粘连。自体和异体EBCs的安全性和有效性也得到了验证。他们的策略适用于一系列的细胞和聚合物。这项工作可能会促进高度细胞化材料的发展和转化，用于出血控制、伤口管理、组织修复和再生医学。

研究人员表示，血凝块是止血和再生的关键，但它们的机械性能较弱，形成缓慢，有可能导致危及生命的大出血，限制了其更广泛的应用。这些限制是由于复杂的混凝级联，大量的机械无效细胞和很少的结构聚合物。加强聚合物网络的策略不适用于这些高度细胞化的材料。

附：英文原文

Title: Engineering tough blood clots for rapid haemostasis and enhanced regeneration

Author: Jiang, Shuaibing, Bao, Guangyu, Yang, Zhen, Wu, Jing, Yang, Xingwei, Kim, Joo Eun June, Jiang, Roselyn, Zhan, Ying, Nottegar, Alexander, Liu, Yin, Gao, Zu-hua, Beckett, Andrew, Nijnik, Anastasia, Long, Rong, Kastrup, Christian, Li, Jianyu

Issue&Volume: 2026-04-29

Abstract: Blood clots are pivotal for haemostasis and regeneration1, but they are mechanically weak and form slowly2, posing risks for life-threatening haemorrhage and limiting broader applications3,4,5. These limitations are attributed to complex coagulation cascades, abundant mechanically ineffective cells and little structural polymers. Strategies that strengthen polymer networks are inapplicable to these highly cellularized materials. Here we report a strategy that rapidly crosslinks red blood cells into tough cytogels and integrates them within blood clots. The resulting engineered blood clots (EBCs) form within seconds and exhibit a 13-fold increase in fracture toughness, and a 4-fold improvement in adhesion energy compared with native clots. Experiments and modelling identify the rupture of mechanically integrated cells as a key toughening mechanism. In vivo studies demonstrate that EBCs can rapidly halt haemorrhage, promote tissue regeneration, mitigate inflammation and foreign body reactions, and prevent postoperative adhesion. The safety and efficacy of both autologous and allogeneic EBCs were also validated. Our strategy is applicable to a range of cells and polymers. This work may motivate the development and translation of highly cellularized materials for bleeding control, wound management, tissue repair and regenerative medicine.

DOI: 10.1038/s41586-026-10412-y

Source: https://www.nature.com/articles/s41586-026-10412-y