课题组发现微管动力学可以作为一个开关来指导心肌细胞的生长。微管稳定性的增加推动细胞增宽，同时沿着细胞宽度重定向mRNA的输出和翻译，并加强嵌入椎间盘。相反，微管稳定性的降低促进了细胞的延长，破坏了嵌入的椎间盘，并使新的肌合成蛋白的翻译和结合偏向于这种结构。值得注意的是，破坏嵌层椎间盘粘连对心肌细胞的延伸是足够的，但对心肌细胞的扩张是必要的。因此，心脏协调局部翻译和结构重塑，协调双向生长。
据了解，成人心脏的生长是通过沿着单个心肌细胞的长度或宽度增加肌节来实现的，但定向生长是如何在空间上协调的尚不清楚。
附：英文原文
Title: Microtubule dynamics control the direction of cardiomyocyte growth
Author: Emily A. Scarborough, Rani M. Randell, Keita Uchida, Kathlyene R. Stone, Kenneth B. Margulies, Benjamin L. Prosser
Issue&Volume: 2026-04-23
Abstract: The adult heart grows by addition of sarcomeres along the length or width of individual cardiomyocytes, yet how directional growth is spatially coordinated remains unclear. Here, we found that microtubule dynamics could act as a toggle to direct cardiomyocyte growth. Increasing microtubule stability drove cellular widening, concomitant with redirecting mRNA export and translation along the width of the cell and reinforcement of the intercalated disc. Conversely, decreasing microtubule stability promoted cellular lengthening, disrupting the intercalated disc and biasing translation and incorporation of new sarcomeric protein toward this structure. Notably, disrupting intercalated disc adhesion was sufficient for cardiomyocyte elongation, yet dispensable for cardiomyocyte widening. Thus, the heart coordinates local translation and structural remodeling to orchestrate bidirectional growth.
DOI: adz1970
Source: https://www.science.org/doi/10.1126/science.adz1970