该课题组人员展示了一个256万个单细胞的转录组图谱，分别覆盖了一只胎猪和它的孕妈妈的115和119个组织。该课题组人员发现，脂肪酸转运能力增强的心脏毛细血管内皮细胞在妊娠期间富集，但妊娠后恢复。该研究团队也破译了滋养细胞中l-亮氨酸运输不足通过减少细胞II型肌纤维亚细胞导致胎儿生长受限。他们的“all-from one”策略能够识别组织细胞类型特异性转录因子，并为妊娠心脏适应和胎儿生长限制提供见解。
研究人员表示，虽然大量的细胞图谱已经可用，但获得单个身体内所有组织的图谱仍然是一个挑战，特别是在胎儿和孕妇中。
附：英文原文
Title: Family single-cell atlases reveal pig pregnancy and fetal growth restriction critical cell types
Author: Liping Cai, Qing Zhang, Tianxiong Yao, Xiaoxiao Zou, Lei Xie, Siyu Yang, Yanyuan Xiao, Fei Huang, Zhiwei Peng, Jiawen Yang, Jianzhen Huang, Qiqi Jing, Ziqi Ling, Min Zheng, Chuanmin Qiao, Jinyuan Wu, Jiaqi Chen, Tao Jiang, Qin Liu, Min Liu, Zhe Chen, Jingquan Li, Hui Jiang, Haoyun Jiang, Zuoquan Chen, Yaya Liao, Yizhong Huang, Longyun Li, Yunyan Zhou, Zhou Zhang, Chao Yin, Yu Ye, Hui Yang, Biao Chen, Zhong Wang, Huanfa Gong, Dong Chen, Cong Huang, Xinkai Tong, Zhimin Zhou, Hao Fu, Yingchun Sun, Xiao Sun, Min Yan, Lin Wu, Shuqi Xiong, Yaxiang Wang, Xinke Xie, Mengqing Zhou, Xiaodong Liu, Xianhua Xie, Fusheng Wu, Zifeng Liu, Mei Ge, Sanya Xiong, Chenyu Li, Tao Shen, Yuxin Liu, Xi Tang, Xiaolong Chang, Siyi Liu, Chuangang Yu, Naixiang Yu, Zikang Hu, Dengshuai Cui, Jiahong Zhong, Sha Liu, Jianchao Hu, Yang Wen, Weiwei Zhou, Guanyue Wei, Shiyao Lin, Yiwen Xiahou, Liqing Chen, Jianjun Li, Ruirong Liu, Xiaoyun Chen, Yujie Shu, Feng Chen, Chao Wei, Xiaofen Hu, Yong Li, Yong Hou, Qingjie Zeng, Jun Gao, Ying Su, Jing Li, Junwu Ma, Yuanmei Guo, Congying Chen, Shijun Xiao, Huashui Ai, Zhiyan Zhang, Weiwei Liu, Qiang Yang, Yuyun Xing, Lin Rao, Bin Yang, Lusheng Huang
Issue&Volume: 2026-03-26
Abstract: Although massive cell atlases are already available, it is still a challenge to obtain an atlas of all tissues within a single body, especially in fetuses and pregnant mothers. We present a transcriptomic atlas of 2.56 million single cells covering 115 and 119 tissues from one fetal pig and its pregnant mother, respectively. We found that a cluster of heart capillary endothelial cells with enhanced fatty acid transit capability was enriched for pregnancy but restored after gestation. We also deciphered that l-leucine transport insufficiency in the trophoblast causes fetal growth restriction by reducing a muscle type II myofiber subcluster. Our “all-from-one” strategy enabled the identification of tissue cell type–specific transcription factors and provided insights into pregnancy heart adaptation and fetal growth restriction.
DOI: adu7265
Source: https://www.science.org/doi/10.1126/science.adu7265