近日，中国科学院深圳先进技术研究院钟超团队报道了利用工程光催化剂-微生物群落从CO₂和H₂O合成光驱动C4生物。2026年3月18日，国际知名学术期刊《美国化学会杂志》发表了这一成果。

利用太阳能将二氧化碳转化为高值化学品的可持续技术开发仍是一项重大挑战。

研究组构建了一种整合Z型光催化剂与工程微生物菌群的生物杂合系统，可在无牺牲剂条件下实现CO₂和H₂O光驱动制备丁二酸。该系统通过表达甲酸脱氢酶的大肠杆菌生物膜实现光电化学CO₂还原产甲酸，并耦合适应性进化的需钠弧菌将甲酸升级转化为丁二酸。该装置在6小时内实现0.06 mM丁二酸产量，表观量子产率达0.154%。

生物膜经四个运行周期仍与光催化剂保持共形接触，同时生物杂合薄板提供的甲酸使需钠弧菌存活率提升11%。同位素示踪进一步证实约20%的碳来自CO₂。研究组通过光催化与合成微生物菌群的理性整合，为太阳能驱动多碳合成建立了可持续平台。

附：英文原文

Title: Light-Driven C4 Biosynthesis from CO2 and H2O via Engineered Photocatalyst–Microbial Consortia

Author: Haiyi Xu, Jicong Zhang, Ke Shi, Jiaming Zhang, Boyang Zhang, Mingming Guo, Xueli Zhang, Ke Li, Guijun Ma, Xiang Gao, Xinyu Wang, Chao Zhong

Issue&Volume: March 18, 2026

Abstract: The development of sustainable technologies for converting CO2 into value-added chemicals using solar energy remains a critical challenge. We presented a biohybrid system integrating Z-scheme photocatalysts with engineered microbial consortia for light-driven succinic acid production from CO2 and H2O without sacrificial agents. The system combined Escherichia coli biofilms expressing formate dehydrogenase for photoelectrochemical CO2 reduction to formate with adaptively evolved Vibrio natriegens for formate upgrading to succinic acid. This configuration achieved 0.06 mM succinic acid in 6 h with an apparent quantum yield of 0.154%. The biofilms maintained conformal contact with photocatalysts through four operational cycles, while V. natriegens viability increased by 11% owing to the formate provided by the biohybrid sheet. Further, isotopic tracing revealed approximately 20% carbon incorporation from CO2. This work establishes a sustainable platform for solar-driven multicarbon synthesis through rational integration of photocatalysis and synthetic microbial consortia.

DOI: 10.1021/jacs.5c16572

Source: https://pubs.acs.org/doi/abs/10.1021/jacs.5c16572