期刊名： Biophysica

期刊主页：https://www.mdpi.com/journal/biophysica

生物系统复杂网络是维系生命活动与调控的核心架构，其多维交互机制与动态演化规律对阐释生理病理过程至关重要。近年来，随着计算建模、多组学数据融合及多尺度动力学模拟等技术取得突破性进展，生物系统研究正从单一组分的静态刻画实现向跨尺度动态交互与系统涌现特性的全景解析跨越。本专题汇集了发表于 Biophysica期刊的计算生物物理系列研究，系统展示了计算模拟、分子对接及分子动力学等计算方法在生物学研究中的前沿探索。系列成果共同勾勒出计算建模赋能系统生物学研究的科学发展蓝图，为复杂生物系统的深入解析与实现精准医疗干预提供了重要范式与理论支撑。

1. Comparative Docking Suggests Peripheral Association of Tirapazamine with Bovine Serum Albumin

比较分子对接结果表明替拉帕明与牛血清白蛋白存在外周关联

http://www.mdpi.com/2673-4125/6/4/73

Gulledge, B.; Uddin, M.G.; Zucker, S.N.; Orozco, G.A.; Rayan, G. Comparative Docking Suggests Peripheral Association of Tirapazamine with Bovine Serum Albumin. Biophysica 2026, 6, 73.

2. Computational Analysis of Microtubule-Mediated Saltatory Neuroelectrical Transmission: A Theoretical Exploration

微管介导的跳跃式神经电传递的计算分析：理论探索

http://www.mdpi.com/2673-4125/6/4/61

Yang, Y.X.; Zhu, B.T. Computational Analysis of Microtubule-Mediated Saltatory Neuroelectrical Transmission: A Theoretical Exploration. Biophysica 2026, 6, 61.

3. Telmisartan-Induced Alteration of Voltage-Gated Na+ Currents: Integrated Experimental and In Silico Approaches

替米沙坦诱导的电压门控钠离子电流改变：实验与计算机模拟相结合的方法

http://www.mdpi.com/2673-4125/6/3/46

Wu, S.-N.; Liutkeviciene, R.; Rovite, V.; Tsai, C.-H.; Lin, S.-C. Telmisartan-Induced Alteration of Voltage-Gated Na+ Currents: Integrated Experimental and In Silico Approaches. Biophysica 2026, 6, 46.

4. Investigating the Role of Inositol 1,4,5-Trisphosphate Receptors in the Pathogenesis of Alzheimer’s Disease Through Computational Modeling

通过计算模型研究肌醇1,4,5-三磷酸受体在阿尔茨海默病发病机制中的作用

http://www.mdpi.com/2673-4125/6/3/42

Akter, S.; Ullah, G.; Ullah, A. Investigating the Role of Inositol 1,4,5-Trisphosphate Receptors in the Pathogenesis of Alzheimer’s Disease Through Computational Modeling. Biophysica 2026, 6, 42.

5. Computational Analysis of Microalgal Proteins with Potential Thrombolytic Effects

微藻蛋白潜在溶栓作用的计算分析

http://www.mdpi.com/2673-4125/6/1/7

Moura, Y.A.S.; Amorim, A.P.d.; Arruda, M.C.S.d.; Silva, M.M.d.; Porto, A.L.F.; Uversky, V.N.; Bezerra, R.P. Computational Analysis of Microalgal Proteins with Potential Thrombolytic Effects. Biophysica 2026, 6, 7.

6. Cell Biophysics—Physiological Contexts, from Organism to Cell, In Vivo to In Silico Models: One Collaboratory’s Perspective

细胞生物物理学——生理背景，从生物体到细胞，从体内到计算机模型：一个合作实验室的视角http://www.mdpi.com/2673-4125/6/1/5

Knothe Tate, M.L.; McBride-Gagyi, S.; Anderson, E.J.; Ngo, L. Cell Biophysics–Physiological Contexts, from Organism to Cell, In Vivo to In Silico Models: One Collaboratory’s Perspective. Biophysica 2026, 6, 5.

7. Computational Modeling Approaches for Optimizing Microencapsulation Processes: From Molecular Dynamics to CFD and FEM Techniques

用于优化微胶囊化工艺的计算建模方法：从分子动力学到CFD和FEM技术

http://www.mdpi.com/2673-4125/5/4/49

Vargas-Rubio, K.I.; Delgado, E.; Cabrales-Arellano, C.P.; Gamboa-Gómez, C.I.; Reyes-Jáquez, D. Computational Modeling Approaches for Optimizing Microencapsulation Processes: From Molecular Dynamics to CFD and FEM Techniques. Biophysica 2025, 5, 49.

8. Screening and Analysis of Potential Inhibitors of SHMT2

SHMT2潜在抑制剂的筛选与分析

http://www.mdpi.com/2673-4125/3/4/44

Chen, B.; Zhang, J.Z.H. Screening and Analysis of Potential Inhibitors of SHMT2. Biophysica 2023, 3, 651-667.

9. Coarse-Grained MD Simulations of Opioid Interactions with the μ-Opioid Receptor and the Surrounding Lipid Membrane

阿片类药物与μ-阿片受体及其周围脂质膜相互作用的粗粒化分子动力学模拟

http://www.mdpi.com/2673-4125/3/2/17

Ray, S.; Fackeldey, K.; Stein, C.; Weber, M. Coarse-Grained MD Simulations of Opioid Interactions with the μ-Opioid Receptor and the Surrounding Lipid Membrane. Biophysica 2023, 3, 263-275.

10. Structural Analysis of Interactions between Epidermal Growth Factor Receptor (EGFR) Mutants and Their Inhibitors

表皮生长因子受体（EGFR）突变体及其抑制剂相互作用的结构分析

http://www.mdpi.com/2673-4125/3/1/13

Guo, Y.; Du, Z.; Shi, T. Structural Analysis of Interactions between Epidermal Growth Factor Receptor (EGFR) Mutants and Their Inhibitors. Biophysica 2023, 3, 203-213.

11. Nascent Adhesion Clustering: Integrin-Integrin and Integrin-Substrate Interactions

新生粘附簇：整合素-整合素和整合素-底物相互作用

http://www.mdpi.com/2673-4125/2/1/4

Lin, K.; Asaro, R.J. Nascent Adhesion Clustering: Integrin-Integrin and Integrin-Substrate Interactions. Biophysica 2022, 2, 34-58.

12. Modelling the Activation Pathways in Full-Length Src Kinase

对全长 Src 激酶的激活通路进行建模

http://www.mdpi.com/2673-4125/1/2/18

Alba, J.; Montagna, M.; D’Abramo, M. Modelling the Activation Pathways in Full-Length Src Kinase. Biophysica 2021, 1, 238-248.

13. Computational Assessment of Modified Antifreeze Glycoproteins on Ice Nucleation

改性抗冻糖蛋白对冰核作用的计算评估

http://www.mdpi.com/2673-4125/1/2/13

Bleszynski, M.; Reil, M. Computational Assessment of Modified Antifreeze Glycoproteins on Ice Nucleation. Biophysica 2021, 1, 168-178.

14. Probing Conformational Dynamics by Protein Contact Networks: Comparison with NMR Relaxation Studies and Molecular Dynamics Simulations

利用蛋白质接触网络探测构象动力学：与核磁共振弛豫研究和分子动力学模拟的比较

http://www.mdpi.com/2673-4125/1/2/12

Chasapis, C.T.; Vlamis-Gardikas, A. Probing Conformational Dynamics by Protein Contact Networks: Comparison with NMR Relaxation Studies and Molecular Dynamics Simulations. Biophysica 2021, 1, 157-167.

15. Molecular Forces Governing the Biological Function of Per-Arnt-Sim-B (PAS-B) Domains: A Comparative Computational Study

调控Per-Arnt-Sim-B (PAS-B)结构域生物学功能的分子力：一项比较计算研究

http://www.mdpi.com/2673-4125/1/1/1

de Souza, J.V.; Zaborniak, P.; Reznikov, S.; Kondal, M.; Zhu, R.; Bronowska, A.K. Molecular Forces Governing the Biological Function of Per-Arnt-Sim-B (PAS-B) Domains: A Comparative Computational Study. Biophysica 2021, 1, 1-14.

期刊介绍

主编：Prof. Dr. Matthias Buck

Case Western Reserve University, USA

Prof. Dr. Victor Muñoz

University of California Merced, USA

Biophysica (ISSN 2673-4125) 创刊于2021年，是一个国际化、经同行评审的开放获取期刊。期刊主要关注生物物理领域的最新技术和研究进展，旨在运用物理、化学和数学的方法和技术，理解生物系统的运作机制，并为探讨和整合生物物理科学与工程的所有层面提供一个多学科交流平台。

•涵盖领域

包括但不限于以下方面：

生物物理学

生物物理方法和技术

生物分子及其组装的结构和动力学

检测、传感和成像技术的新方法

细胞生物物理学

生物系统理论与建模

生物工程、纳米技术和生物材料

量子生物学

生物物理学的起源和历史

生物力学、传感和信号传导

2025 Impact Factor：1.8

2025 CiteScore：2.6

Time to First Decision：19.1 Days

Acceptance to Publication：4.7 Days