通过在拟南芥中建模和实验的结合，课题组揭示了一个缓冲环境信号的负反馈回路。该环由促进不确定性的先锋转录因子LEAFY （LFY）和促进不确定性的转录协同抑制因子TERMINAL FLOWER1 （TFL1）组成。在向开花生殖期过渡时，LFY直接定量上调TFL1的表达。TFL1反过来负反馈LFY，以防止LFY过度积累。即使在强烈的花诱导信号下，这也阻止了花序的终止。他们的工作揭示了一种涉及两个细胞群对相同环境刺激的不同反应的机械环境缓冲机制。
研究人员表示，开花植物的花序采用不同的遗传程序和环境调节结构。相比之下，顶端分生组织中干细胞池的持续维持对环境因素没有反应。
附：英文原文
Title: A negative feedback loop between TERMINAL FLOWER1 and LEAFY protects inflorescence indeterminacy
Author: Tian Huang, Charles Hodgens, Sandhan Prakash, Marco Marconi, Krzysztof Wabnik, Rosangela Sozzani, Doris Wagner
Issue&Volume: 2026-01-22
Abstract: Inflorescences of flowering plants adopt diverse genetically programmed and environmentally tuned architectures. By contrast, continued maintenance of the stem-cell pool within the apical meristem is unresponsive to environmental cues. Through a combination of modeling and experimentation in Arabidopsis, we reveal a negative feedback loop that buffers environmental signals. This loop comprises the determinacy-promoting pioneer transcription factor LEAFY (LFY) and the indeterminacy-promoting transcriptional co-repressor TERMINAL FLOWER1 (TFL1). At the transition to the flower-producing reproductive phase, LFY directly and quantitatively up-regulates expression of TFL1. TFL1 in turn negatively feeds back on LFY to prevent LFY overaccumulation. This blocks inflorescence termination even under strong florally inductive signals. Our work uncovers a mechanism for robust environmental buffering involving differential responses of two cell populations to the same environmental stimulus.
DOI: adv5429
Source: https://www.science.org/doi/10.1126/science.adv5429