近日，英国牛津大学Michael C. Willis团队报道了通过能量转移催化获得四元环磺酰亚胺。相关论文于2026年1月8日发表在《科学》杂志上。

通过激发态推进的合成转化遵循非常规的机理途径，并产生基态化学无法获得的产物。这些有合成价值的转化反应，其应用广度受限于可产生有效激发态的分子范围（特别是官能团），而大多数方法使用的同类官能团都是100多年前定义的。

在这项工作中，研究组表明N-硅基磺酰亚胺可通过能量转移催化剂和可见光获得有合成价值的激发态反应性。研究组利用这些中间体与烯烃反应形成四元环磺酰胺产物。这些反应效率高，底物范围广，产物可进一步转化为磺酰胺及四元环磺酰亚胺类化合物。

附：英文原文

Title: Access to four-membered cyclic sulfinamides by energy transfer catalysis

Author: Di Zhai, Benedict A. Williams, Loc R. E. Pantaine, Yiding Chen, Michael C. Willis

Issue&Volume: 2026-01-08

Abstract: Synthetic transformations that advance through excited states proceed by unconventional mechanistic pathways and deliver products not accessible using ground-state chemistry. The breadth of these synthetically valuable transformations is constrained by the range of molecules—and particularly the functional groups—that can deliver productive excited states, with most methods using the same functional groups that were defined more than 100 years ago. In this work, we show that N-silyl sulfinylamines can undergo synthetically useful excited-state reactivity accessed using energy transfer catalysts and visible light. We exploit these intermediates in reactions with alkenes to form four-membered cyclic sulfinamide products. The reactions are efficient and broad in scope, and the products are advanced to sulfonamides as well as four-membered cyclic sulfonimidamides.

DOI: aec3158

Source: https://www.science.org/doi/10.1126/science.aec3158