近日，美国哈佛大学Aziz, Michael J.团队报道了用软界面分子介质催化工业过氧化氢生产。相关论文于2025年9月22日发表在《自然-化学》杂志上。

过氧化氢是通过蒽醌自氧化法制备的，这是一种典型的热催化非水法。尽管人们对利用可再生电力驱动这一过程非常感兴趣，但使非水化合物合成通电仍然是一个重大挑战。

研究组提出了一种多相电化学蒽醌自氧化过程，该过程利用了异质分子介导的水-非水界面质子耦合电子传递方法。这种设计能够在高电流密度下高效地还原水基蒽醌，仅以碳电极为主题。该方法通过醌醌中间体具有高选择性，并且在热催化加氢过程中防止了芳烃的过度还原。这种方法结合了水性电化学和传统非水性工艺的优点，实现了具有快速动力学和质量传递的高电流密度电化学，同时避免了过氧化氢产物中不需要的电解质。这一策略将水电化学与非水化学连接起来，并为其他非水化学过程的电气化和分散化建立了框架。

附：英文原文

Title: Electrifying industrial hydrogen peroxide production via soft interfacial molecular mediation

Author: Xi, Dawei, Wu, Yuheng, Li, Yuli, Yan, Zifei, Liu, Richard Y., Aziz, Michael J.

Issue&Volume: 2025-09-22

Abstract: Hydrogen peroxide is manufactured industrially via the anthraquinone autoxidation process—a typical thermocatalytic non-aqueous method. Despite a high interest in using renewable electricity to drive such processes, electrifying non-aqueous syntheses remains a substantial challenge. Here we present a multi-phase electrochemical anthraquinone autoxidation process that leverages an aqueous–non-aqueous interfacial proton-coupled electron transfer method facilitated by heterogeneous molecular mediation. This design enables the reduction of aqueous anthraquinones with high efficiency at high current densities, using only carbon electrodes. The method operates with high selectivity through a quinhydrone intermediate and prevents the over-reduction of aromatics during thermocatalytic hydrogenation. This approach combines the benefits of aqueous electrochemistry with those of the traditional non-aqueous process to achieve high current density electrochemistry with rapid kinetics and mass transport, while avoiding unwanted electrolyte in the hydrogen peroxide product. This strategy bridges aqueous electrochemistry with non-aqueous chemistry and establishes a framework for the electrification and decentralization of other non-aqueous chemical processes.

DOI: 10.1038/s41557-025-01940-7

Source: https://www.nature.com/articles/s41557-025-01940-7