近日，吉林大学卢革宇团队实现了用于近红外成像和光热治疗的高效发光稳定奇奇巴宾二根碱。相关论文于2025年8月26日发表在《光：科学与应用》杂志上。

双根碱类化合物因其独特的电子、光物理性质和在功能材料中的潜在应用而受到广泛关注。具有窄带隙和近红外（NIR）吸收的特点，是NIR引导光热治疗的有前景的候选者。然而，由于高化学反应性和非常有效的内部转换，它们通常不稳定，并表现出非发射性质。

研究组报道了一种非常稳定的菊苣素二根碱TT-CzPh，它具有近红外发光（λ_em=821）有效光致发光量子产率（PLQY）为6.4%。令人惊讶的是，TT-CzPh不仅具有出色的近红外成像能力，而且具有高达87.5%的光热转换效率（PCE）。体内实验证明了TT-CzPh纳米颗粒在近红外成像引导下对肿瘤光消融的有效性。这项工作不仅促进了稳定、高效发光的奇奇巴宾碳氢化合物的开发，而且为生物成像和癌症光疗应用开辟了新的途径。

附：英文原文

Title: Efficient luminescent stable Chichibabin diradicaloid for near-infrared imaging and photothermal therapy

Author: Liu, Ting, Zhu, Zihao, Wang, Shengjie, Shen, Li, Abdurahman, Alim, Liu, Xiaomin, Lu, Geyu

Issue&Volume: 2025-08-26

Abstract: Diradicaloids have garnered significant attention due to their unique electronic, photophysical properties and potential applications in functional materials. Characterized by a narrow band gap and near-infrared (NIR) absorption, diradicaloids are promising candidates for NIR-guided photothermal therapy. However, they are often unstable and exhibit non-emissive properties due to high chemical reactivity and very efficient internal conversion. Herein, we report a remarkably stable Chichibabin diradicaloid, TT-CzPh, which exhibits NIR luminescence (λem=821nm) with an efficient photoluminescence quantum yield (PLQY) of 6.4%. Surprisingly, TT-CzPh not only exhibits excellent NIR imaging but also has a very high photothermal conversion efficiency (PCE) of 87.5%. In vivo experiments with TT-CzPh nanoparticles demonstrated their effectiveness in tumor photoablation guided by NIR imaging. This work not only advances the development of stable, efficient luminescent Chichibabin’s hydrocarbons but also opens new avenues for bioimaging and cancer phototherapy applications.

DOI: 10.1038/s41377-025-01993-w

Source: https://www.nature.com/articles/s41377-025-01993-w