小组发现，在狨猴中，使dlPFC 46区失活会使食欲动机变得迟钝，并提高威胁反应性。这种影响是不对称的——仅依赖于左半球——并通过投射到孕前扣带区32来介导。抗抑郁药氯胺酮通过胼胝体下扣带区25的机制阻断了食欲动机缺陷，该区域与dlPFC无创刺激治疗成功有关。他们的数据揭示了46区的综合前额叶网络，该网络有助于积极和消极的情绪调节，这可能是他们理解难治性抑郁和焦虑的症状和治疗策略的核心。
据介绍，背外侧前额叶皮层（dlPFC）是针对治疗难治性抑郁症的非侵入性刺激的高阶大脑结构。尽管如此，它在情绪调节中的宣泄作用尚不清楚。
附：英文原文
Title: Dysfunction in primate dorsolateral prefrontal area 46 affects motivation and anxiety
Author: Christian M. Wood, Rana Banai Tizkar, Martina Fort, Xinhu Zhang, Kevin G. Mulvihill, Naixuan Liao, Gemma J. Cockcroft, Lauren B. McIver, Stephen J. Sawiak, Angela C. Roberts
Issue&Volume: 2025-08-21
Abstract: The dorsolateral prefrontal cortex (dlPFC) is a higher-order brain structure targeted for noninvasive stimulation for treatment-resistant depression. Nonetheless, its causal role in emotion regulation is unknown. We discovered that inactivating dlPFC area 46 in marmosets blunts appetitive motivation and heightens threat reactivity. The effects were asymmetric—dependent on the left hemisphere only—and were mediated through projections to pregenual cingulate area 32. The antidepressant ketamine blocked the appetitive motivational deficits through mechanisms within subcallosal cingulate area 25, an area linked with treatment success in dlPFC noninvasive stimulation. Our data uncover an integrated prefrontal network for area 46 that contributes to positive and negative emotion regulation that may be core to our understanding of symptoms and therapeutic strategies for treatment-resistant depression and anxiety.
DOI: adx4142
Source: https://www.science.org/doi/10.1126/science.adx4142