该课题组研究人员通过单核RNA测序分析了从出生到成年的人类海马。研究团队确定了儿童早期所有的神经祖细胞阶段。在成人中，针对增殖标记Ki67和机器学习算法的主题抗体，课题组研究人员发现了增殖的神经祖细胞。
此外，转录组学数据显示，神经祖细胞位于齿状回内。这些结果有助于理解成人的神经发生。
据了解，成人海马神经发生与记忆形成和情绪调节有关，但对人类的研究具有挑战性。发现增殖祖细胞的困难使人们对新神经元能否产生以及如何产生产生产生了疑问。
附：英文原文
Title: Identification of proliferating neural progenitors in the adult human hippocampus
Author: Ionut Dumitru, Marta Paterlini, Margherita Zamboni, Christoph Ziegenhain, Sarantis Giatrellis, Rasool Saghaleyni, sa Bjrklund, Kanar Alkass, Mathew Tata, Henrik Druid, Rickard Sandberg, Jonas Frisén
Issue&Volume: 2025-07-03
Abstract: Continuous adult hippocampal neurogenesis is involved in memory formation and mood regulation but is challenging to study in humans. Difficulties finding proliferating progenitor cells called into question whether and how new neurons may be generated. We analyzed the human hippocampus from birth through adulthood by single-nucleus RNA sequencing. We identified all neural progenitor cell stages in early childhood. In adults, using antibodies against the proliferation marker Ki67 and machine learning algorithms, we found proliferating neural progenitor cells. Furthermore, transcriptomic data showed that neural progenitors were localized within the dentate gyrus. The results contribute to understanding neurogenesis in adult humans.
DOI: adu9575
Source: https://www.science.org/doi/10.1126/science.adu9575