四川大学余达刚团队近日研究了可见光驱动的硫酸盐催化烯烃与CO₂的碳羧化反应：容易合成恶吲哚-3-乙酸衍生物。相关论文于2025年6月10日发表在《中国化学》杂志上。

研究组提出了一种通过催化电子供体-受体（EDA）复合物活化烯烃与CO₂的可见光驱动碳羧化反应。从N-芳基丙烯酰胺和二氧化碳中以中等至优异的收率生产了各种羟吲哚-3-乙酸及其衍生物。机理研究表明，催化硫醇盐和烯烃之间形成了EDA络合物。值得注意的是，这种氧化还原中性反应具有温和、无过渡金属和光催化剂的条件、良好的官能团耐受性和广泛的底物范围。此外，天然产物中关键中间体的简易合成突显了这种方法的实用性。

附：英文原文

Title: Visible-Light-Driven Thiolate-Catalyzed Carbo-Carboxylation of Alkenes with CO2: Facile Synthesis of Oxindole-3-acetic Acid Derivatives

Author: You-Yang Jiang, Zhen Chen, Yuan-Xu Jiang, Wen-Jing Zhu, Jin-Cheng Xu, Jian-Heng Ye, Wei Zhang, Da-Gang Yu

Issue&Volume: 2025-06-10

Abstract: Herein, we present a visible-light-driven carbo-carboxylation of alkenes with CO2 via catalytic electron donor-acceptor (EDA) complex activation. A variety of oxindole-3-acetic acid and derivatives were generated in moderate to excellent yields from N-arylacrylamides and CO2. Mechanistic studies revealed the formation of an EDA complex between catalytic thiolate and alkene. Notably, this redox-neutral reaction features mild, transition-metal and photocatalyst-free conditions, good functional group tolerance and broad substrate scope. Furthermore, the facile synthesis of key intermediates in natural products underscores the utility of this methodology.

DOI: 10.1002/cjoc.70115

Source: https://onlinelibrary.wiley.com/doi/10.1002/cjoc.70115