复旦大学张荣君团队实现了双步光诱导自组装水凝胶用于内源性口腔黏膜伤口愈合。2025年5月15日，《光：科学与应用》杂志发表了这一成果。

将压电材料引入水凝胶口腔敷料中，在应力刺激下产生微电场，促进口腔伤口愈合。然而，为了适应口腔潮湿和动态的环境，传统的“一步一步”合成往往需要不同功能的材料组合。鉴于这些材料之间的性质差异，这种策略通常涉及复杂的实验程序和不必要的能源消耗。

研究组以“一体化构建”为理念，创新性地提出了双步光诱导方法，成功制备出性能优异的复合水凝胶。他们在ZnO中引入了丰富的氧空位，利用增强的界面动力学来实现持续的光诱导效应。该方法以双网状聚合物框架为模板，无需额外的特殊实验条件和复杂的操作程序，即可在水凝胶中实现光诱导原位合成聚多巴胺（PDA）。

研究团队对这种光诱导方法的机制进行了深入的分析，并将制备好的水凝胶用于口腔伤口的治疗，由于水凝胶出色的综合性能，明显加快了愈合过程。这些结果为基于光动力学原理的高性能水凝胶的快速构建提供了新的思路和理论支持，显示了未来在伤口敷料中的巨大应用潜力。

附：英文原文

Title: Dual-step photo-induced self-assembled hydrogel for endogenous oral mucosal wound healing

Author: Fang, Shaojun, Zhou, Qiangqiang, Zhou, Mengqi, Li, Changyi, Xu, Huaxing, Tang, Hongyu, Zhang, Wanlu, Guo, Ruiqian, Wei, Xiaoling, Zhang, Rongjun

Issue&Volume: 2025-05-15

Abstract: By introducing piezoelectric materials into hydrogel oral dressings, a microelectric field could be generated under stress stimulation, thus facilitating oral wound healing. However, to adapt to the moist and dynamic environment of the oral cavity, traditional “step-by-step” synthesis often requires the combination of materials with different functionalities. Given the property differences between these materials, this strategy typically involves complex experimental procedures and unnecessary energy consumption. In this study, with the concept of “integrated construction”, we innovatively proposed a dual-step photo-induced method and successfully fabricated composite hydrogels with excellent performance. We introduced abundant oxygen vacancies into ZnO, leveraging the enhanced interface dynamics to achieve sustained photo-induced effect. With a double-network polymer framework as a template, this method could achieve the photo-induced spontaneous in-situ synthesis of polydopamine (PDA) within hydrogel without any extra special experimental conditions and complex operation procedures. We conducted a thorough analysis of the mechanism underlying this photo-induced method and applied the as-prepared hydrogel for the treatment of oral wounds, which significantly accelerated the healing process due to the outstanding comprehensive performance of hydrogel. These results suggest novel ideas and theoretical support for the facile construction of high-performance hydrogels based on photodynamic principles, demonstrating immense potential for future applications in wound dressings.

DOI: 10.1038/s41377-025-01837-7

Source: https://www.nature.com/articles/s41377-025-01837-7