课题组人员发现Thetis细胞的一个子集TC IV是食物特异性pTreg细胞分化所必需的。TC IV几乎完全存在于肠系膜淋巴结内，这表明TC IV的存在是口服耐受现象的基础。断奶前后的TC IV分化与对食物抗原反应增强pTreg生成的机会窗口有关。他们的研究结果表明，TC IV可能是治疗食物相关过敏性和炎症性疾病的治疗靶点。
据悉，在肠道内，外周诱导的调节性T细胞（pTreg）在抑制对食物蛋白的炎症反应中发挥重要作用。然而，指导食物特异性pTreg细胞的抗原呈递细胞（APC）的身份尚不清楚。
附：英文原文
Title: A wave of Thetis cells imparts tolerance to food antigens early in life
Author: Vanja Cabric, Yollanda Franco Parisotto, Tyler Park, Blossom Akagbosu, Zihan Zhao, Yun Lo, Gayathri Shibu, Logan Fisher, Yoselin A. Paucar Iza, Christina Leslie, Chrysothemis C. Brown
Issue&Volume: 2025-05-15
Abstract: Within the intestine, peripherally-induced regulatory T (pTreg) cells play an essential role in suppressing inflammatory responses to food proteins. However, the identity of antigen-presenting cells (APC) that instruct food-specific pTreg cells is poorly understood. Here, we found that a subset of Thetis cells, TC IV, is required for food-specific pTreg cell differentiation. TC IV were almost exclusively present within mesenteric lymph nodes suggesting that the presence of TC IV underlies the phenomenon of oral tolerance. A wave of TC IV differentiation in the peri-weaning period was associated with a window of opportunity for enhanced pTreg generation in response to food antigens. Our findings indicate that TC IV may represent a therapeutic target for the treatment of food-associated allergic and inflammatory diseases.
DOI: adp0535
Source: https://www.science.org/doi/10.1126/science.adp0535