近日，美国芝加哥大学教授Ralph R. Weichselbaum及其研究组研制了辐射诱导的双调节蛋白驱动肿瘤转移。该项研究成果发表在2025年5月14日出版的《自然》上。

在这里，课题组研究人员表明放射治疗诱导肿瘤细胞中EGFR配体双调节蛋白的表达，这将表达EGFR的骨髓细胞重编程为免疫抑制表型并减少吞噬。这刺激了人类患者和临床前肿瘤模型的远处转移生长。放射治疗对这些促肿瘤因子的抑制可能是一种改善患者预后的新治疗策略。

据介绍，放射治疗在治疗领域之外的抗肿瘤作用——体外效应——引起了人们极大的兴趣。然而，辐射在促进肿瘤转移中的潜在有害作用尚未得到充分研究。

附：英文原文

Title: Radiation-induced amphiregulin drives tumour metastasis

Author: Piffk, Andrs, Yang, Kaiting, Panda, Arpit, Heide, Janna, Tesak, Krystyna, Wen, Chuangyu, Zawieracz, Katarzyna, Wang, Liangliang, Naccasha, Emile Z., Bugno, Jason, Fu, Yanbin, Chen, Dapeng, Donle, Leonhard, Lengyel, Ernst, Tilley, Douglas G., Mack, Matthias, Rock, Ronald S., Chmura, Steven J., Vokes, Everett E., He, Chuan, Pitroda, Sean P., Liang, Hua Laura, Weichselbaum, Ralph R.

Issue&Volume: 2025-05-14

Abstract: The anti-tumour effect of radiotherapy beyond the treatment field—the abscopal effect—has garnered much interest1. However, the potentially deleterious effect of radiation in promoting metastasis is less well studied. Here we show that radiotherapy induces the expression of the EGFR ligand amphiregulin in tumour cells, which reprogrammes EGFR-expressing myeloid cells toward an immunosuppressive phenotype and reduces phagocytosis. This stimulates distant metastasis growth in human patients and in pre-clinical mouse tumour models. The inhibition of these tumour-promoting factors induced by radiotherapy may represent a novel therapeutic strategy to improve patient outcomes.

DOI: 10.1038/s41586-025-08994-0

Source: https://www.nature.com/articles/s41586-025-08994-0