华南师范大学陈宜法团队近日研究了用于千级C-S键合产物生成的三相间接电解系统。相关论文于2025年5月12日发表在《中国化学》杂志上。

开发环境友好、成本效益高、大规模电合成抗癌药物的新策略，以取代高成本的传统方法，实现高原子经济性，是非常可取的。GW 610是一种抗肿瘤剂，在实际的医疗过程中对肺癌、结肠癌和乳腺癌癌症细胞系具有有效和选择性的抗癌活性，其市场价格约为10⁷美元/公斤，需要采用电合成等新方法来降低成本。研究组首次设计了一种基于微波合成的多金属氧酸盐基金属有机框架（MW-POMOF）的固液气三相间接电解系统，该系统可以将S-S键底物转化为有价值的C-S键产物，如抗癌药物分子（如GW 610）。 

具体而言，固相MW-POMOF作为非均相氧化还原介质，对液相C-S键产物的形成（产率高达95%）表现出优异的电催化效率，同时产生气相H₂产物（~402 μmol·g^-1·^h-1），从而形成了一个有趣的三相间接电解系统。值得注意的是，它能够以市场价格的千分之一（从10⁷美元/公斤到3200美元/公斤）实现GW 610的公斤级生产（批量实验中约1公斤）。这项工作可能为探索电催化领域的多孔晶体材料开辟一条新的电催化途径。

附：英文原文

Title: A Three-Phase Indirect Electrolysis System for Kilo-scale Generation of C–S Bond Products

Author: Gang Liu, Xianqiang Huang, Yingjie Li, Shiqi Fu, Guodong Shen, Zhen Li, Yalin Zhang, Qingde Zhang, Fei Yu, Yifa Chen

Issue&Volume: 2025-05-12

Abstract: The development of new strategy for environmentally friendly, cost-effective and large-scale electro-synthesis of anticancer drugs is highly desirable to replace high-cost traditional methods and realize high atomic economy. GW 610, an antitumor agent with potent and selective anticancer activity against lung, colon, and breast cancer cell lines in real medical treatment processes, has a market price of ~107 USD/kg and calls for novel methods like electro-synthesis to reduce the cost. Here, for the first time, we design a solid-liquid-gas three-phase indirect electrolysis system based on a kind of microwave-synthesized polyoxometalate-based metal-organic framework (MW-POMOF) that can converse S–S bond substrates into valuable C–S bond products like anticancer drug molecules (e.g., GW 610). Specifically, the solid-phase MW-POMOF as heterogeneous redox mediator exhibits the excellent electrocatalytic efficiency for the formation of liquid-phase C–S bond products (yields up to 95%) coupling with the generation of gas-phase H2 product (~402 μmol·g–1·h–1), resulting in an interesting three-phase indirect electrolysis system. Remarkably, it enables the kilo-scale production (~1 kg in a batch experiment) of GW 610 at one thousandth of the market price (from ~107 to ~3200 USD/kg). This work may inaugurate a new electrocatalytic avenue to explore porous crystalline materials in electrocatalysis field.

DOI: 10.1002/cjoc.70068

Source: https://onlinelibrary.wiley.com/doi/full/10.1002/cjoc.70068