美国霍华德休斯医学院Jeffrey C. Magee课题组宣布他们的研究开发出了海马体CA1区经验依赖的位置细胞参照机制。这一研究成果发表在2025年4月1日出版的国际学术期刊《自然—神经科学》上。

在这里，研究小组纵向记录了头部固定的小鼠在跑步机上执行空间学习任务时的PC活动。在熟悉的环境中，CA1表征由PC组成，这些PC以大约相等的比例被引用到特定的空间位置或奖励目标；然而，CA1表示在暴露于新环境时主要是目标参考，因为空间参考PC自适应地切换参考帧。细胞膜电位记录显示，单个CA1神经元同时接受空间参考和目标参考的突触输入，这些输入的比例与单个PC参考相关。

此外，行为时间尺度突触可塑性形成PC参考。总之，这些结果表明突触输入的经验依赖调整塑造了PC参考，以支持灵活的认知地图。

据介绍，海马体CA1位置细胞（pc）编码空间和目标参考信息，以支持认知地图。这种参照的机制和经验的作用仍然知之甚少。

附：英文原文

Title: Mechanisms of experience-dependent place-cell referencing in hippocampal area CA1

Author: Qian, Fish Kunxun, Li, Yiding, Magee, Jeffrey C.

Issue&Volume: 2025-04-01

Abstract: Hippocampal CA1 place cells (PCs) encode both space- and goal-referenced information to support a cognitive map. The mechanism of this referencing and the role of experience remain poorly understood. Here we longitudinally recorded PC activity while head-fixed mice performed a spatial learning task on a treadmill. In a familiar environment, the CA1 representation consisted of PCs that were referenced to either specific spatial locations or a reward goal in approximately equal proportions; however, the CA1 representation became predominately goal-referenced upon exposure to a novel environment, as space-referenced PCs adaptively switched reference frames. Intracellular membrane potential recordings revealed that individual CA1 neurons simultaneously received both space- and goal-referenced synaptic inputs, and the ratio of these inputs was correlated with individual PC referencing. Furthermore, behavioral timescale synaptic plasticity shaped PC referencing. Together, these results suggest that experience-dependent adjustment of synaptic input shapes PC referencing to support a flexible cognitive map.

DOI: 10.1038/s41593-025-01930-5

Source: https://www.nature.com/articles/s41593-025-01930-5