近日，澳门大学曲松楠团队研究了J型组装Pt（IV）配位碳点用于近红外光引发的焦亡。该项研究成果发表在2025年4月15日出版的《光：科学与应用》杂志上。

基于生物相容性铂（IV）协同纳米药物的近红外（NIR）光触发焦凋亡用于肿瘤精确治疗是一个挑战。

研究组揭示了一种超分子方法，通过超声辅助Pt（IV）配位碳点（Pt-CDs）的J型组装来构建空心球形超碳点（HS-Pt-CDs）。由Pt（IV）原子在sp²结构域内配位而成的碗状Pt-CDs中，由于空间位阻和晶格畸变而产生了特殊的组装行为，这导致约240nm的红移吸收带，并由于HS-Pt-CDs中的强分子间电荷转移（CT）而促进NIR区域的电荷分离。

结果表明，HS-Pt-CDs在690nm激光照射下表现出优异的近红外光激活光催化能力，包括Pt（II）物种的释放、羟基自由基的产生和酸化。结合有效的细胞摄取和肿瘤积聚，HS-Pt-CDs可在690 nm下有效触发癌症细胞焦下垂激光照射，破坏原发肿瘤，有效诱导强免疫原性细胞死亡（ICD），从而激发抗肿瘤免疫反应，抑制远处肿瘤，防止癌症转移。基于这些优点，含Pt（IV）的超CD具有出色的近红外触发光催化行为，这对精确的肿瘤光疗具有重要意义。

附：英文原文

Title: J-type assembled Pt(IV)-coordinated carbon dots for near-infrared light-triggered pyroptosis

Author: Guo, Dongbo, Hou, Yijie, Xu, Qin, Wang, Bingzhe, Zhang, Tesen, Cheng, Quansheng, Chen, Maohua, Huang, Linxuan, Xing, Guichuan, Qu, Songnan

Issue&Volume: 2025-04-15

Abstract: Near-infrared (NIR) light-triggered pyroptosis based on biocompatible Pt(IV)-coordinated nanomedicine for tumor precision therapy is challenging. Here, we disclose a supramolecular approach to construct a hollow-spherical supra-(carbon dots) (HS-Pt-CDs) via ultrasound-assisted J-type assembly of Pt(IV)-coordinated carbon dots (Pt-CDs). The peculiar assembling behaviors arise from the steric hindrance and lattice distortion in the bowl-like Pt-CDs caused by the coordination of Pt(IV) atoms among the sp2 domains, which result in around 240nm red-shifted absorption bands and promoting charge separation in the NIR region due to strong inter-molecular charge transfer (CT) in HS-Pt-CDs. The results reveal that HS-Pt-CDs exhibit excellent NIR light-activated photocatalytic capacities, involving the release of Pt(II) species, the generation of hydroxyl radicals, and acidification under 690nm laser irradiation. Combined with the effective cellular uptake and tumor accumulation, HS-Pt-CDs can efficiently trigger cancer cell pyroptosis under 690nm laser irradiation, resulting in the destruction of the primary tumor and effectively induction of strong immunogenic cell death (ICD), thereby evoking anti-tumor immune responses to suppress distant tumor and prevent cancer metastasis. Taken these merits, an important perspective of Pt(IV)-contained supra-CDs with outstanding NIR-triggered photocatalytic behaviors can be of great significance toward precision tumor phototherapy.

DOI: 10.1038/s41377-025-01834-w

Source: https://www.nature.com/articles/s41377-025-01834-w