中国科学院自动化研究所蒋田仔课题组发现，小鼠、猕猴与人脑网络中富人俱乐部特性的演化：功能整合、分离与平衡研究。2025年4月13日出版的《神经科学通报》发表了这项成果。

在本研究中，该课题组人员首次利用神经元追踪或扩散磁共振成像数据在猴、猴和人的大脑结构网络中检测并验证了富人俱乐部。此外，该课题组人员评估了富人俱乐部在功能整合、隔离和平衡主题量化指标方面的作用。他们的研究结果表明，富人俱乐部的存在促进了所有三种物种的全脑功能整合，而高等物种的功能网络表现出更大的整合。这些发现将有助于从大脑进化的角度理解大脑结构与功能之间的关系。

据悉，富人俱乐部作为节点高度互联的社区，是网络的拓扑中心。然而，富人俱乐部如何支持不同物种大脑功能整合和分离的异同仍然未知。

附：英文原文

Title: Evolution of the Rich Club Properties in Mouse, Macaque, and Human Brain Networks: A Study of Functional Integration, Segregation, and Balance

Author: Zhang, Xiaoru, Song, Ming, Jiang, Wentao, Lu, Yuheng, Chu, Congying, Li, Wen, Wang, Haiyan, Shi, Weiyang, Lan, Yueheng, Jiang, Tianzi

Issue&Volume: 2025-04-13

Abstract: The rich club, as a community of highly interconnected nodes, serves as the topological center of the network. However, the similarities and differences in how the rich club supports functional integration and segregation in the brain across different species remain unknown. In this study, we first detected and validated the rich club in the structural networks of mouse, monkey, and human brains using neuronal tracing or diffusion magnetic resonance imaging data. Further, we assessed the role of rich clubs in functional integration, segregation, and balance using quantitative metrics. Our results indicate that the presence of a rich club facilitates whole-brain functional integration in all three species, with the functional networks of higher species exhibiting greater integration. These findings are expected to help to understand the relationship between brain structure and function from the perspective of brain evolution.

DOI: 10.1007/s12264-025-01393-5

Source: https://link.springer.com/article/10.1007/s12264-025-01393-5