合成凝聚物和生物分子凝聚物向超稳定和自发乳化方向的普遍膜化，这一成果由华南理工大学蒋凌翔团队经过不懈努力而取得。2025年4月10日出版的《自然—化学》杂志发表了这一最新研究成果。

在这里，研究人员开发了一个缩合两亲嵌段聚合物库，可以有效地在液滴界面上形成聚合物层，用于广泛的合成缩合物和生物分子缩合物。缩合两亲嵌段聚合物被设计成亲缩合嵌段牢固地固定在缩合相上，疏缩合嵌段延伸到稀相上，自缔合嵌段促进膜的形成。其设计的关键是苯硼酸和氨基胺的亲冷凝块，通过多价亲和作用靶向冷凝液滴的不同化学反应。缩合型两亲嵌段聚合物膜使液滴在机械上抵抗离子，调节渗透性和刚度等界面特性，并大大提高液滴对温度、盐度、pH和有机溶剂等恶劣条件的耐受性。

研究人员表示，无膜凝聚体和凝析物的膜化正成为解决其固有的对离子、成熟和环境变化的易感性的一种有前途的策略。然而，目前的膜化剂在设计上很大程度上局限于一个子类或一种特定的凝聚或凝聚系统。

附：英文原文

Title: Universal membranization of synthetic coacervates and biomolecular condensates towards ultrastability and spontaneous emulsification

Author: Tang, Da, Zhu, Jun, Wang, Hao, Chen, Nannan, Wang, Hui, Huang, Yongqi, Jiang, Lingxiang

Issue&Volume: 2025-04-10

Abstract: Membranization of membraneless coacervates and condensates is emerging as a promising strategy to resolve their inherent susceptibility to fusion, ripening and environmental variations. Yet current membranization agents by design are largely limited to a subclass or a specific kind of coacervate or condensate systems. Here we develop a library of condensate-amphiphilic block polymers that can efficiently form a polymeric layer on the droplet interface for a wide spectrum of synthetic coacervates and biomolecular condensates. Condensate-amphiphilic block polymers are designed with a condenophilic block firmly anchored to the condensed phase, a condenophobic block extended to the dilute phase and a self-association block to promote membrane formation. Critical to our design is the condenophilic block of phenylboronic acid and amidoamine that target the disparate chemistry of condensed droplets via multivalent affinities. The condensate-amphiphilic block polymer membranes render the droplets mechanically robust against fusion, regulate interfacial properties such as permeability and stiffness, and substantially improve droplet tolerance to challenging conditions of temperature, salinity, pH and organic solvents.

DOI: 10.1038/s41557-025-01800-4

Source: https://www.nature.com/articles/s41557-025-01800-4