课题组人员发现了一个独特的启动阶段，有利于表达对抗原具有高亲和力的受体的CD8 T细胞。CXCR3的表达需要CD8 T细胞在淋巴结的特异性滤泡壁龛中与DCs长时间的再结合。CD4 T细胞在CD8 T细胞和DC相互作用的部位短暂发病，并在移动到另一个DC之前提供白细胞介素-2 （IL-2）。他们的研究结果强调了T细胞启动过程中一个以前未被认识到的细胞-细胞相互作用阶段，并对疫苗接种和细胞免疫治疗具有直接意义。
据悉，T细胞启动的特征是初始激活阶段涉及与树突状细胞（DC）的稳定相互作用。激活的T细胞脱离DC并恢复迁移后，如何接收分化所需的旁分泌信号尚不清楚。
附：英文原文
Title: A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals
Author: Katarzyna Jobin, Deeksha Seetharama, Lennart Rüttger, Chloe Fenton, Ekaterina Kharybina, Annerose Wirsching, Anfei Huang, Konrad Knpper, Tsuneyasu Kaisho, Dirk H. Busch, Martin Vaeth, Antoine-Emmanuel Saliba, Frederik Graw, Alain Pulfer, Santiago F. González, Dietmar Zehn, Yinming Liang, Milas Ugur, Georg Gasteiger, Wolfgang Kastenmüller
Issue&Volume: 2025-04-11
Abstract: T cell priming is characterized by an initial activation phase that involves stable interactions with dendritic cells (DCs). How activated T cells receive the paracrine signals required for their differentiation once they have disengaged from DCs and resumed their migration has been unclear. We identified a distinct priming phase that favors CD8 T cells expressing receptors with high affinity for antigen. CXCR3 expression by CD8 T cells was required for their hours-long reengagement with DCs in specific subfollicular niches in lymph nodes. CD4 T cells paused briefly at the sites of CD8 T cell and DC interactions and provided Interleukin-2 (IL-2) before moving to another DC. Our results highlight a previously unappreciated phase of cell-cell interactions during T cell priming and have direct implications for vaccinations and cellular immunotherapies.
DOI: adq1405
Source: https://www.science.org/doi/10.1126/science.adq1405