河北工业大学苏伟怡小组报道磁场强化D-psicose反溶剂-冷却耦合结晶的研究。相关论文发表在2025年3月3日出版的《颗粒学报》杂志上。

D-psicose是一种罕见的糖，目前因其独特的功能和医疗潜力而吸引了更多的关注。它主要是通过DTE或DPE将果糖转化，然后经过纯化和结晶步骤得到的。在本研究中，开发了一种创新的反向抗溶剂冷却耦合结晶工艺，以生产产率高且晶体尺寸合理的D-psicose。具体来说，抗溶剂乙醇的加入降低了整个体系的粘度，这在一定程度上改善了传质过程，而冷却过程保证了高收率，因为D-psicose的溶解度随着温度的升高而下降。

在研究过程中，通过响应面法对耦合工艺进行优化，获得了84%的收率。通过对过饱和的精确调节，使结晶尺寸增大到266 μm，适合下游过滤、干燥等。为了进一步提高工业生产效率，在整个过程中以磁场为主题加强结晶过程，使总结晶时间从普通的70-195 h缩短到50 h。可以认为，新型反向抗溶剂-冷却耦合结晶有利于高效生产高质量的D-psicose。

附：英文原文

Title: Study on the coupled reverse antisolvent-cooling crystallization of D-psicose intensified by magnetic field

Author: Weiyi Su a b

Issue&Volume: 2025/03/03

Abstract: D-psicose is a rare sugar that has currently attracted more attention for its unique functionality and medical potential. It is mainly obtained by converting fructose through DTE or DPE, followed by purification and crystallization steps. In this study, an innovative coupled reverse antisolvent-cooling crystallization process was developed to produce D-psicose with high yield and reasonable crystal size. Specifically, the usage of antisolvent ethanol decreased the viscosity of the whole system, which somehow improved the mass transfer process, while the cooling process ensured the high yield since the solubility of D-psicose was found to drop with temperature. During the study, the coupled process was optimized through response surface methodology, and the yield of 84% was obtained. With the precise regulation to supersaturation, the crystal size was enlarged to 266 μm, which was suitable for downstream filtration, drying etc. To further intensify the industrial productivity, a magnetic field was used throughout to intensify the crystallization process, with which the total crystallization duration was shortened to 50 h from common 70-195 h. It is believable that the new coupled reverse antisolvent-cooling crystallization was advantageous to efficiently produce D-psicose with high quality.

DOI: 10.1016/j.partic.2025.02.010

Source: https://www.sciencedirect.com/science/article/abs/pii/S167420012500046X