近日，教授天津大学宋东坡及其研究小组开发出具有精确链结构的支链嵌段共聚物的可扩展连续合成的高性能流动化学平台。相关论文于2025年2月24日发表于国际顶尖学术期刊《中国高分子科学杂志》杂志上。

在此，该课题组开发了一个流动化学平台，用于连续微流合成以接枝为主题的瓶溴嵌段共聚物（BBCPs）。这涉及到在串联的两个微流控反应器中对两种不同的大单体进行开环复分解聚合（ROMP）。理论模拟和实验结果都表明，由于Z形通道具有优异的混合效率，微流环境允许在几十秒内完成单体转化。因此，通过连续过程的自动化，可以在一天内生成多达528个不同样品的定义良好的bbcp库，同时保持对聚合度（DP<4）和多分散性指数（PDI<1.2）的精确控制。该合成方法一般适用于具有不同组成和长度的不同大单体，生成了物理化学性质和链结构差异很大的支链嵌段共聚物库。这项工作为高通量生产支链共聚物提供了一个强大的平台，降低了实际应用的材料成本。

研究人员表示，前沿研究主要集中在线性嵌段共聚物的流动合成上，缺乏对链结构进行更广泛应用的能力。

附：英文原文

Title: High-performance Flow Chemistry Platform for Scalable Continuous Synthesis of Branched Block Copolymers with Precise Chain Structures

Author: Bang-Bang Wang, Zhuang Zhang, Jing-Tao Wang, Li Pan, Yue-Sheng Li, Dong-Po Song

Issue&Volume: 2025-02-24

Abstract: Cutting-edge research has primarily focused on flow synthesis of linear block copolymers, lacking the ability for manipulating chain architectures for more extensive applications. Herein, we develop a flow chemistry platform for the continuous microflow synthesis of bottlebrush block copolymers (BBCPs) using a grafting-through method. This involves performing ring-opening metathesis polymerization (ROMP) of two different macromonomers within two microfluidic reactors connected in series. The microflow environment allows for complete monomer conversion within a few tens of seconds, benefiting from the superior mixing efficiency achieved in Z-shaped channels as indicated by both theoretical simulations and experimental results. Consequently, a library of well-defined BBCPs of up to 528 distinct samples can be produced within one day through automation of the continuous procedure, while keeping precise control on degree of polymerization (DP<4) and polydispersity indices (PDI<1.2). The synthetic method is generally applicable to different macromonomers with different compositions and contour lengths, yielding libraries of branched block copolymers with great diversity in physiochemical properties and chain architectures. This work presents a powerful platform for high-throughput production of branched copolymers, significantly lowering the costs of the materials for real applications.

DOI: 10.1007/s10118-025-3273-2

Source: https://www.cjps.org/en/article/doi/10.1007/s10118-025-3273-2/