德国亚琛工业大学Oliver Pabst团队揭示了克隆持续性主导肠道内稳态IgA反应。2025年12月1日，国际知名学术期刊《免疫学》发表了这一成果。

然而，研究小组缺乏对IgA反应如何在诱导位点和效应位点之间进行时间整合的详细了解。小组从诱导室和肠固有层作为主要效应室的克隆库的角度剖析稳态IgA反应。该课题组发现独特的克隆模式在肠道诱导位点中占主导地位，并且肠道固有层中的浆细胞（PC）克隆需要分化的渐进阶段。该团队证明，不断多样化的重复克隆持续播种肠道PC群体。这些观察结果表明，是克隆而不是细胞寿命塑造了IgA反应，而周期性克隆的动态调节可能会平衡肠道PC库的稳定性和灵活性。

据悉，免疫球蛋白A （IgA）是产生最丰富的抗体同型，在粘膜表面介导保护和稳态调节。稳态IgA的产生受到多种途径的支持，包括肠诱导淋巴组织中的慢性生发中心。

附：英文原文

Title: Clonal persistence dominates homeostatic intestinal IgA responses

Author: Britta Simons, Hieu Trong Nguyen, Atscharah Panyot, Fabian Tobias Hager, Johanna Kabbert, Asmae Laouina, Jonathan Schreiber, Lydia Kopplin, Tim Rollenske, Thomas Clavel, Oliver Pabst

Issue&Volume: 2025-12-01

Abstract: Immunoglobulin A (IgA) is the most abundantly produced antibody isotype and mediates protection and homeostatic regulation at mucosal surfaces. Steady-state IgA production is supported by multiple pathways, including chronic germinal centers in gut inductive lymphoid tissues. However, we lack a detailed understanding of how IgA responses are temporally integrated across inductive and effector sites. Here, we dissect homeostatic IgA responses from the perspective of clonal repertoires in inductive compartments and the gut lamina propria as the main effector compartment. We show that unique clonal patterns dominate across gut inductive sites and that plasma cell (PC) clones in gut lamina propria entail progressive stages of differentiation. We demonstrate that ongoing diversification of recurrent clones continuously seeds the gut PC population. These observations suggest that clonal rather than cellular longevity shapes IgA responses and that dynamic modulation of recurrent clones may balance stability and flexibility of the gut PC repertoire.

DOI: 10.1016/j.immuni.2025.11.005

Source: https://www.cell.com/immunity/abstract/S1074-7613(25)00507-2