威斯康星大学Chiara Cirelli课题组近日取得一项新成果。经过不懈努力，他们研制了海马体“尖波睡眠”状态与皮质睡眠分离。相关论文发表在2025年12月11日出版的《自然—神经科学》杂志上。

在这里，研究组对雄性大鼠进行了连续48小时的神经像素记录，以捕捉睡眠/觉醒周期中的海马活动。该研究组发现，海马尖波（SPWs）以及在某种程度上，波纹和齿状突起（DSs）密切反映了睡眠需求。海马SPWs发生在行为睡眠期间，与皮层慢波不同，它也发生在安静的清醒期间。皮层觉醒期间海马SPW、纹波和DS的表达与随后的皮层睡眠期间呈负相关，表明这些事件具有相似的内稳态功能。

此外，在SPW期间，慢速对快速伽马比始终很高，这与切换到部分断开模式相一致。研究小组认为SPWs定义了海马体的一种部分断开的、自我平衡调节的统一状态，研究小组称之为“海马体尖波睡眠”。

据介绍，皮层慢波反映了对睡眠的需求，它们的存在表明了一种断开连接和自我平衡调节的状态。然而，除了大脑皮层，研究团队对睡眠需求的神经信号知之甚少。

附：英文原文

Title: A hippocampal ‘sharp-wave sleep’ state that is dissociable from cortical sleep

Author: Findlay, Graham, Cavelli, Matias Lorenzo, Bugnon, Tom, Marshall, William, Tononi, Giulio, Cirelli, Chiara

Issue&Volume: 2025-12-11

Abstract: Cortical slow waves reflect the need for sleep, and their presence indicates a state of disconnection and homeostatic regulation. However, little is known about the neural signatures of sleep need beyond the cortex. Here we performed chronic, continuous, 48-h Neuropixels recordings in male rats to capture hippocampal activity over sleep/wake cycles. We show that hippocampal sharp waves (SPWs) and, to some extent, ripples and dentate spikes (DSs) closely reflect sleep need. Hippocampal SPWs occurred during behavioral sleep and, unlike cortical slow waves, also during quiet wake. The expression of hippocampal SPW, ripple and DS during cortical wakefulness was negatively correlated with that during subsequent cortical sleep, suggesting that these events fulfill similar homeostatic functions. Moreover, the slow-to-fast gamma ratio was always high during SPW, consistent with a switch to a partially disconnected mode. We propose that SPWs define a partially disconnected, homeostatically regulated, unitary state of the hippocampus, which we refer to as ‘hippocampal sharp wave sleep’.

DOI: 10.1038/s41593-025-02141-8

Source: https://www.nature.com/articles/s41593-025-02141-8