近日，哈尔滨工程大学杨飘萍团队报道了通过Fe³⁺占据的B位掺杂在稀土六角锰酸盐中进行极化工程和化学键重建，用于压电催化治疗和铁死亡。这一研究成果于2025年11月5日发表在《美国化学会志》上。

压电催化疗法已成为一种无创治疗策略。然而，其治疗效果受到压电材料中载流子（电子和空穴）分离效率低的限制。稀土六方锰矿材料具有较高的压电响应、居里温度和相对较窄的光学带隙，可能是高效压电催化治疗的良好候选者。

研究组报道了一种用于压电催化治疗的稀土六方锰矿材料[铁（Fe）掺杂钇锰矿（YMnO₃）纳米颗粒（YMn_O3:Fe NPs）]的设计。通过极化工程引入Fe掺杂剂，增加了锰氧化物（MnO₅）三角形双棱锥结构中YMnO₃:Fe晶格的倾斜角，增强了晶体的不对称性、自发极化和压电性能。同时，密度泛函理论计算表明，Mn-O共价增加，Fe-O-Mn键角畸变协同降低了能垒，实现了定向电子迁移，最大限度地减少了效率损失。

超声照射下，YMnO₃:Fe NPs表现出双酶-压催化的催化放大效应，触发肿瘤细胞凋亡。这种级联效应通过抑制谷胱甘肽过氧化物酶4和酰基辅酶a合成酶长链家族成员4上调，增加细胞内活性氧的产生，引发细胞凋亡和铁死亡，从而抑制体内肿瘤的生长。这些发现突出了稀土六方锰矿材料在推进癌症治疗策略方面的巨大潜力。

附：英文原文

Title: Polarization Engineering and Chemical Bond Reconstruction in Rare-Earth Hexagonal Manganite via Fe3+-Occupied B-Site Doping for Piezocatalytic Therapy and Ferroptosis

Author: Meiqi Yang, Lu Yang, Shili Gai, Meichen Li, Haijiang Gong, Ping’an Ma, Piaoping Yang

Issue&Volume: November 5, 2025

Abstract: Piezocatalytic therapy has emerged as a noninvasive therapeutic strategy. However, its therapeutic effect is limited by the low separation efficiency of carriers (electrons and holes) in piezoelectric materials. Rare-earth hexagonal manganite materials might be good candidates for efficient piezocatalytic therapy because of their high piezoelectric response, Curie temperature, and relatively narrow optical bandgaps. Herein, we report the design of a rare-earth hexagonal manganite material [iron (Fe)-doped yttrium manganite (YMnO3) nanoparticles (YMnO3:Fe NPs)] for piezocatalytic therapy. The introduction of Fe dopants through polarization engineering increased the tilt angle in the manganese oxide (MnO5) triangular bipyramidal structure in the YMnO3:Fe lattice, enhancing the crystal asymmetry, spontaneous polarization, and piezoelectric performance. Concurrently, density functional theory calculation revealed that Mn–O covalency increased and Fe–O–Mn bond angle distortion reduced energy barriers synergistically, enabling directional electron migration for minimizing efficiency loss. Under ultrasound irradiation, YMnO3:Fe NPs exhibited a dual enzymatic–piezocatalytic catalytic amplification effect to trigger tumor-cell apoptosis. This cascade effect increased the generation of intracellular reactive oxygen species triggered apoptosis and ferroptosis via glutathione peroxidase 4 suppression and acyl–CoA synthetase long-chain family member 4 upregulation, which inhibited in vivo tumor growth. These findings highlighted the significant potential of rare-earth hexagonal manganite materials for the advancement of cancer therapeutic strategies.

DOI: 10.1021/jacs.5c14530

Source: https://pubs.acs.org/doi/abs/10.1021/jacs.5c14530