上海交通大学贾伟平团队取得一项新突破。他们研制了在糖耐量正常的受试者中，靶向炎性蛋白质组学与胰岛素敏感性和β细胞功能之间的关系。这一研究成果于2025年11月4日发表在国际顶尖学术期刊《分子细胞生物学报》上。

该课题组的目的是研究炎症相关蛋白（IRPs）与NGT受试者胰岛素动力学之间的关系。对1109名年龄在40-44岁、体重正常或超重的非糖尿病受试者和21名年龄在22-32岁的中国NGT受试者进行了数据分析，并进行了准确的代谢评估。使用Olink技术检测IRP。采用高胰岛素-正糖钳和高糖钳分别评价胰岛素敏感性和β细胞功能。在NGT受试者中发现了8个与肥胖相关的因子，其中MCP-3、IL-6、TWEAK、HGF和CST5在非糖尿病患者中也有关联。他们的IRPs与胰岛素敏感性有关，其中IL-24是一个新发现。7种IRPs与β细胞功能相关，包括新的相关因子CD244、CD40和IL-15RA。

此外，大多数IRP以IL-6为枢纽相互连接。总之，胰岛素敏感性和β细胞功能与参与趋化、免疫细胞活化和细胞增殖的IRPs有关，这可能为了解T2D发病机制提供有价值的信息。

据介绍，即使糖耐量（NGT）正常的肥胖者，患2型糖尿病（T2D）的风险也更高，而且肥胖与炎症有关。然而，NGT个体中炎症与β细胞功能和胰岛素敏感性之间的联系机制尚不完全清楚。

附：英文原文

Title: Association between targeted inflammatory proteomics and insulin sensitivity as well as beta-cell function in subjects with normal glucose tolerance

Author: Chen, Anran, Li, Qian, Mao, Hongfeng, Lu, Yuwei, Liu, Dan, Zhang, Lei, Fang, Qichen, Wang, Chen, Li, Huating, Jia, Weiping

Issue&Volume: 2025-11-04

Abstract: Obese individuals even with normal glucose tolerance (NGT) are at higher risk for developing type 2 diabetes (T2D), and obesity is associated with inflammation. However, mechanisms linking inflammation to beta-cell function and insulin sensitivity in NGT individuals are not fully understood. We aimed to investigate the relationships between inflammation-related proteins (IRPs) and insulin dynamics in NGT subjects. The explorations were conducted using data from 1109 non-diabetes subjects aged 40–44 with normal or excess body weight and 21 Chinese NGT subjects aged 22–32 with accurate metabolic assessment. IRPs were detected with Olink technology. Insulin sensitivity and beta-cell function were evaluated with hyperinsulinemic–euglycemic clamp and hyperglycemic clamp. Eight associators were identified with obesity in NGT subjects, among which MCP-3, IL-6, TWEAK, HGF, and CST5 also showed associations in non-diabetes people. Four IRPs were linked to insulin sensitivity, with IL-24 being a novel finding. Seven IRPs were related to beta-cell function, including novel associators CD244, CD40, and IL-15RA. Moreover, most IRPs were interconnected, with IL-6 as the hub. In conclusion, insulin sensitivity and beta-cell function are related to IRPs involved in chemotaxis, activation of immune cells, and cell proliferation, which might provide valuable information for the understanding of the mechanisms associated with T2D pathogenesis.

DOI: 10.1093/jmcb/mjaf035

Source: https://dx.doi.org/10.1093/jmcb/mjaf035