中国农业科学院杜雄明小组的最新研究揭示了综合代谢组学和转录组学分析鉴定了陆地棉MYB基因调控关键代谢物和农艺性状。该研究于2025年11月3日发表于国际一流学术期刊《自然—遗传学》杂志上。

本研究整合了403个陆地棉花胚珠的多组学数据，鉴定出2960个代谢数量性状位点和24485个表达数量性状位点。一个关键位点，ME_A07，影响252个已知代谢物水平和4293个基因的表达，MYB基因GhTT2_A07被确定为中心调控因子，可能由520kb反演。GhTT2_A07调控初级和次级代谢物的生物合成，影响农艺性状。另一个位点ME_A06，由MYB基因原花青素调节因子（GhPAR）驱动，调节原花青素含量，提示具有生态适应性。GhTT2_A07和GhPAR表现出共享和不同的表达谱，对纤维质量和产量有不同的贡献。这些发现强调了MYB基因在棉花胚珠和纤维早期发育中的关键作用，为棉花研究和分子育种提供了全面的多组学研究资源。

据介绍，了解早期胚胎发育是揭示植物细胞分化和器官发生的基础。

附：英文原文

Title: Integrated metabolomic and transcriptomic analyses identify MYB genes regulating key metabolites and agronomic traits in upland cotton Gossypium hirsutum

Author: Zhang, Xiaomeng, Tian, Xinquan, Gao, Xueke, Sun, Gaofei, Peng, Zhen, Geng, Xiaoli, Peng, Jun, Dai, Panhong, Wang, Xiao, Li, Hongge, Wang, Zhenzhen, Pan, Zhaoe, Jia, Yinhua, Chen, Baojun, Hu, Daowu, Wang, Liru, Pang, Baoyin, Xing, Aishuang, Lu, Shuai, Gao, Xu, Dai, Congyang, Wei, Xi, Zhang, Haobo, Cui, Jinjie, He, Shoupu, Ma, Lei, Du, Xiongming

Issue&Volume: 2025-11-03

Abstract: Understanding early embryonic development is fundamental for unraveling plant cell differentiation and organogenesis. Here we integrate multiomics data from 403 upland cotton ovules to identify 2,960 metabolic quantitative trait loci and 24,485 expression quantitative trait loci. A key locus, ME_A07, influencing 252 known metabolite levels and expression of 4,293 genes, with the MYB gene GhTT2_A07 identified as central regulator, potentially regulated by a 520kb inversion. GhTT2_A07 orchestrated both primary and secondary metabolite biosynthesis, influencing agronomic traits. Another locus, ME_A06, driven by the MYB gene Proanthocyanidin Regulator (GhPAR), modulates proanthocyanin content and suggests an ecological adaptation. GhTT2_A07 and GhPAR exhibit both shared and distinct expression profiles, contributing variably to fiber quality and yield. These findings highlight the critical role of MYB genes in the early development of cotton ovules and fibers, offering comprehensive multiomics resources that advance cotton research and molecular breeding.

DOI: 10.1038/s41588-025-02363-3

Source: https://www.nature.com/articles/s41588-025-02363-3