本文综述了跨膜和细胞外空间（meTPD）的TPD，并分析了平台技术、特点、应用和局限性。研究人员将重点讨论以发展当前meTPD技术为主题的概念创新，以及它在生物研究和治疗干预方面的潜在价值。
研究人员表示，跨膜蛋白和细胞外蛋白在多种细胞功能和通讯中起着至关重要的作用，通过介导重要的细胞过程影响各种细胞疾病的进展和治疗。尽管靶向蛋白降解（TPD）代表了一种先进的治疗方式，它利用细胞降解机制来消除感兴趣的蛋白质，但目前的策略主要局限于细胞内靶标。现在，针对跨膜和细胞外蛋白的新兴策略正在迅速扩大这一强大技术的视野。
附：英文原文
Title: Targeted protein degradation in the transmembrane and extracellular space
Author: Rongfeng Zhu, Heng Zhang, Peng R. Chen
Issue&Volume: 2025-11-27
Abstract: Transmembrane and extracellular proteins play crucial roles in diverse cellular functions and communication, affecting the progression and treatment of various diseases by mediating vital cellular processes. Whereas targeted protein degradation (TPD) represents an advancing therapeutic modality that leverages cellular degradation machinery to eliminate proteins of interest, present strategies have been largely confined to intracellular targets. Now, emerging strategies toward transmembrane and extracellular proteins are rapidly expanding the horizon of this powerful technology. Here, we review TPD in the transmembrane and extracellular space (meTPD) and discuss platform technologies, features, applications, and limitations. We focus on the conceptual innovations used in developing the present meTPD technology as well as its potential value for biological research and therapeutic interventions.
DOI: adx5094
Source: https://www.science.org/doi/10.1126/science.adx5094