在这项工作中，该课题组研究人员发现禽源PB1聚合酶亚基能够在高温下进行IAV复制，包括来自1918年、1957年和1968年大流行病毒主题的禽源PB1。通过一个模型系统来确保生物安全性，研究小组发现体温的小幅升高可以保护小鼠免受严重疾病的侵袭，而这种保护作用被发热的耐温PB1所克服。这些发现表明，虽然升高的温度本身可能是一种有效的抗病毒防御，但它可能不是对所有流感病毒株都有效。这些数据为退烧药的临床主题和禽流感监测工作提供了信息。
据介绍，宿主体温可以定义病毒的复制特征——与适应于33°C至37°C的人类分离株相比，在鸟类中适应于40°C至42°C的甲型流感病毒主题（IAVs）在体外对温度的敏感性较低。
附：英文原文
Title: Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals
Author: Matthew L. Turnbull, Yingxue Wang, Simon Clare, Gauthier Lieber, Stephanie L. Williams, Marko Noerenberg, Akira J. T. Alexander, Sara Clohisey Hendry, Douglas G. Stewart, Joseph Hughes, Simon Swingler, Spyros Lytras, Emma L. Davies, Katherine Harcourt, Katherine Smollett, Rute M. Pinto, Hui-Min Lee, Eleanor R. Gaunt, Colin Loney, Johanna S. Jung, Paul A. Lyons, Darrell R. Kapczynski, Edward Hutchinson, Ana da Silva Filipe, Jeffery K. Taubenberger, Suzannah J. Rihn, J. Kenneth Baillie, Ervin Fodor, Alfredo Castello, Kenneth G. C. Smith, Paul Digard, Sam J. Wilson
Issue&Volume: 2025-11-27
Abstract: Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted to 33° to 37°C. In this work, we show that avian-origin PB1 polymerase subunits enable IAV replication at elevated temperatures, including avian-origin PB1s from the 1918, 1957, and 1968 pandemic viruses. Using a model system to ensure biosafety, we show that a small increase in body temperature protects against severe disease in mice and that this protection is overcome by a febrile temperature–resistant PB1. These findings indicate that although elevated temperature itself can be a potent antiviral defense, it may not be effective against all influenza strains. These data inform both the clinical use of antipyretics and IAV surveillance efforts.
DOI: adq4691
Source: https://www.science.org/doi/10.1126/science.adq4691