近日，Jayeeta Basu及其研究团队报道了皮层谷氨酸能和GABA能输入支持学习驱动的海马稳定性。2025年10月30日，国际知名学术期刊《科学》发表了这一成果。

该团队发现，侧内鼻皮层谷氨酸能（LECGLU）和gaba能（LECGABA）向CA3的投射招募了特定的微电路，这些微电路联合起来为支持学习的神经元群提供稳定性。LECGLU驱动CA3的兴奋，但也有实质性的前馈抑制，防止体细胞和树突尖峰。相反，LECGABA通过选择性地促进体细胞输出到整合的LECGLU和CA3循环输入，通过室和途径特异性抑制这种局部抑制去抑制CA3活性。这种协同作用使得与学习相关的空间表征稳定，因为LECGLU和LECGABA都控制着CA3位置细胞在不同环境和时间中的形成和维持。

据悉，神经元群的灵活性和稳定性是大脑功能的重要特征。对于本地电路的这些特性如何受到远程输入的影响，研究团队知之甚少。

附：英文原文

Title: Cortical glutamatergic and GABAergic inputs support learning-driven hippocampal stability

Author: Vincent Robert, Keelin O’Neil, Jason J. Moore, Shannon K. Rashid, Cara D. Johnson, Rodrigo G. De La Torre, Boris V. Zemelman, Claudia Clopath, Jayeeta Basu

Issue&Volume: 2025-10-30

Abstract: Flexibility and stability of neuronal ensembles are crucial features of brain function. Little is known about how these properties of local circuits are influenced by long-range inputs. We show that lateral entorhinal cortex glutamatergic (LECGLU) and GABAergic (LECGABA) projections to CA3 recruit specific microcircuits that conjunctively provide stability to neuronal ensembles supporting learning. LECGLU drives excitation in CA3 but also substantial feedforward inhibition that prevents somatic and dendritic spikes. Conversely, LECGABA suppresses this local inhibition to disinhibit CA3 activity with compartment- and pathway-specificity by selectively boosting somatic output to integrated LECGLU and CA3 recurrent inputs. This synergy allows the stabilization of spatial representations relevant to learning, as both LECGLU and LECGABA control the formation and maintenance of CA3 place cells across contexts and over time.

DOI: adn0623

Source: https://www.science.org/doi/10.1126/science.adn0623