星形胶质细胞集群充当多日痕迹以稳定记忆，这一成果由日本RIKEN脑科学中心Jun Nagai团队经过不懈努力而取得。相关论文于2025年10月15日发表在《自然》杂志上。

在这里，课题组人员确定了一个星形细胞集合，该星形细胞集合由情感体验转录启动，并由重复体验在功能上触发，以稳定不稳定的记忆。使用一种新颖的全脑Fos标记和成像方法，课题组发现星形细胞Fos集合优先在神经元印迹区域被招募，并且在恐惧回忆期间比在条件反射期间更广泛。

研究组建立了星形胶质细胞集合的诱导机制，该机制包括两个步骤：(1)最初的恐惧经历诱导星形胶质细胞状态随去甲肾上腺素受体的上调而持续一整天的缓慢变化；(2)回忆过程中去甲肾上腺素反应增强，这是一种重复的经历，使星形胶质细胞能够整合来自局部印迹和远程去甲肾上腺素能投射的一致信号，从而诱导继发性星形胶质细胞状态改变，包括Fos和神经调节分子IGFBP2的上调。星形胶质细胞集合信号调节印迹的药理和遗传扰动，以及记忆的稳定性和准确性。在经历依赖性神经活动后，星形胶质细胞集合作为星形胶质细胞子集的多日痕迹，有资格捕获未来重复的经历以稳定记忆。

据介绍，回忆的记忆变得短暂不稳定，需要稳定。对生存至关重要的经历的记忆通常在情感上是突出的和重复的，其稳定记忆的机制尚不清楚。

附：英文原文

Title: The astrocytic ensemble acts as a multiday trace to stabilize memory

Author: Dewa, Ken-ichi, Kaseda, Kodai, Kuwahara, Aoi, Kubotera, Hideaki, Yamasaki, Ayato, Awata, Natsumi, Komori, Atsuko, Holtz, Mika A., Kasai, Atsushi, Skibbe, Henrik, Takata, Norio, Yokoyama, Tatsushi, Tsuda, Makoto, Numata, Genri, Nakamura, Shun, Takimoto, Eiki, Sakamoto, Masayuki, Ito, Minako, Masuda, Takahiro, Nagai, Jun

Issue&Volume: 2025-10-15

Abstract: Recalled memories become transiently labile and require stabilization1,2,3. The mechanism for stabilizing memories of survival-critical experiences, which are often emotionally salient and repeated, remains unclear4. Here we identify an astrocytic ensemble that is transcriptionally primed by emotional experience and functionally triggered by repeated experience to stabilize labile memory. Using a novel brain-wide Fos tagging and imaging method, we found that astrocytic Fos ensembles were preferentially recruited in regions with neuronal engrams5 and were more widespread during fear recall than during conditioning. We established the induction mechanism of the astrocytic ensemble, which involves two steps: (1) an initial fear experience that induces day-long, slow astrocytic state changes with noradrenaline receptor upregulation; and (2) enhanced noradrenaline responses during recall, a repeated experience, enabling astrocytes to integrate coincident signals from local engrams and long-range noradrenergic projections, which induce secondary astrocytic state changes, including the upregulation of Fos and the neuromodulatory molecule IGFBP2. Pharmacological and genetic perturbation of the astrocytic ensemble signalling modulate engrams, and memory stability and precision. The astrocytic ensemble thus acts as a multiday trace in a subset of astrocytes after experience-dependent neural activity, which are eligible to capture future repeated experiences for stabilizing memories.

DOI: 10.1038/s41586-025-09619-2

Source: https://www.nature.com/articles/s41586-025-09619-2